4-methyl-N-(2-methyl-1-phenyl-butyl)-benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(2-methyl-1-phenyl-butyl)-benzenesulfonamide
• 英文别名: N-p-Toluolsulfonyl-1-phenyl-2-methyl-n-butylanilin；4-methyl-N-(2-methyl-1-phenylbutyl)benzenesulfonamide
• 化学式: C₁₈H₂₃NO₂S
• 分子量: 317.452
• InChiKey: GXEWKBDUIMPXRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-碘丁烷 、 N-tosylbenzaldimine 在 氯化铵 、 锌 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到4-methyl-N-(2-methyl-1-phenyl-butyl)-benzenesulfonamide
  参考文献：
  名称：

  Miyabe, Hideto; Ueda, Masafumi; Naito, Takeaki, Chemical Communications, 2000, # 20, p. 2058 - 2060

  摘要：

  DOI：

文献信息

• Evaluation of phenylorganotellurium compounds as radical precursors in dialkylzinc-mediated radical addition to CN double bonds
  作者：Fabien Cougnon、Laurence Feray、Samantha Bazin、Michèle P. Bertrand

  DOI：10.1016/j.tet.2007.09.014

  日期：2007.11

  Diethylzinc-mediated radical addition to CN bonds was investigated in the presence of phenylorganotellurium compounds as radical precursors. As group transfer agents, secondary alkyl phenyl tellurides were shown to be about twice as reactive as the corresponding alkyl iodides towards ethyl radical. Their use was proven to be advantageous regarding both chemoselectivity and yield. The replacement of

  在苯基有机碲化合物作为自由基前体的存在下，研究了二乙基锌介导的向CN键的自由基加成反应。作为基团转移剂，仲烷基苯基碲化物的反应活性约为相应的烷基碘对乙基的两倍。事实证明，它们的使用在化学选择性和产率方面都是有利的。用二甲基锌代替二乙基锌在这些反应中没有优势。
• Carbon radical addition to N-sulfonylimines mediated by triethylborane or zinc
  作者：Masafumi Ueda、Hideto Miyabe、Okiko Miyata、Takeaki Naito

  DOI：10.1016/j.tet.2008.12.031

  日期：2009.2

  The utility of N-sulfonylimines as radical acceptors was investigated under the different reaction conditions such as the stannyl radical-mediated addition reaction, the triethylborane-mediated tin-free radical reaction, and the zinc-mediated aqueous-medium radical reaction. The alkyl radical addition reaction of N-sulfonylimines proceeded effectively without the activation by Lewis acid. These reactions were successfully extended to one-pot reactions for preparing a wide range of amine derivatives. (C) 2008 Elsevier Ltd. All rights reserved.
• Miyabe, Hideto; Ueda, Masafumi; Naito, Takeaki, Chemical Communications, 2000, # 20, p. 2058 - 2060
  作者：Miyabe, Hideto、Ueda, Masafumi、Naito, Takeaki

  DOI：——

  日期：——