(5S,6R,7E,9E,11Z,14Z)-6-[(2-amino-2-carboxyethyl)sulfanyl]-5-hydroxyicosa-7,9,11,14-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6R,7E,9E,11Z,14Z)-6-[(2-amino-2-carboxyethyl)sulfanyl]-5-hydroxyicosa-7,9,11,14-tetraenoic acid
• 英文别名: (5S,6R,7E,9E,11Z,14Z)-6-(2-amino-2-carboxyethyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
• 化学式: C₂₃H₃₇NO₅S
• 分子量: 439.6
• InChiKey: OTZRAYGBFWZKMX-MPWKMEBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  30
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• ANAPHYLAXIS ASSAY
  申请人：Worm, Margitta

  公开号：EP3121600A1

  公开（公告）日：2017-01-25

  The invention relates to a method for diagnosing an anaphylactic reaction / anaphylaxis in a patient, comprising the steps of determining a concentration of 9α,11β-PGF2 in a sample obtained from said patient; and assigning to said sample a high likelihood of anaphylaxis if said concentration of 9α,11β-PGF2 is above a predetermined PGF threshold (cut-off), particularly a threshold which is at least two standard deviations above a baseline level determined for a population of control patients, wherein said control patients are not suffering from anaphylaxis or a threshold which is equal to or higher than 170 pg/ml.

  本发明涉及一种诊断患者过敏反应/过敏性休克的方法，包括以下步骤：确定从患者处获得的样本中 9α，11β-PGF2 的浓度；如果所述 9α，11β-PGF2 的浓度高于预定的 PGF 阈值（临界值），特别是高于为对照组患者人群确定的基线水平至少两个标准差的阈值（其中所述对照组患者未患过敏性休克）或等于或高于 170 PG/ml 的阈值，则将过敏性休克的高可能性归因于所述样本。
• USE OF PLATELET ACTIVATING FACTOR ANTAGONISTS AS ANTI-PRURITIC AGENTS
  申请人：ALLERGAN, INC.

  公开号：EP0532512A1

  公开（公告）日：1993-03-24
• EP0532512A4
  申请人：——

  公开号：EP0532512A4

  公开（公告）日：1993-05-05
• INHIBITORS OF LEUKOTRIENE-MEDIATED ACTIVITY FOR TREATING SIDE EFFECTS OF STATIN THERAPY
  申请人：Yeda Research and Development Co., Ltd.

  公开号：EP3107626A1

  公开（公告）日：2016-12-28
• FOOD ALLERGY BIOMARKER, FOOD ALLERGY TESTING METHOD, KIT FOR URINE SAMPLE TESTING, AND STICK FOR URINE SAMPLE TESTING
  申请人：The University of Tokyo

  公开号：US20190049472A1

  公开（公告）日：2019-02-14

  This biomarker is a biomarker for testing a food allergy, and comprises at least one species selected from the group consisting of LTE 4 , 14,15-LTE 4 , 11-trans LTE 4 , 11-dehydro 11-dehydro TXB 2 , 2,3-dinor-8-iso Prostaglandin F 2α , 13,14-dihydro-15-keto-tetranor PGF 1β , 6,15-diketo-13,14-dihydro PGF 1α , tetranor-PGFM, 20-OH PGE 2 , PGE 3 , PGD 3 , 13,14-dihydro-15-keto-tetranor PGD 2 , and 13,14-dihydro-15-keto-tetranor PGE 2 .