4,7,10,13-Docosatetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4,7,10,13-Docosatetraenoic acid
• 英文别名: (4E,7E,10E,13E)-docosa-4,7,10,13-tetraenoic acid
• 化学式: C₂₂H₃₆O₂
• 分子量: 332.5
• InChiKey: WSCPRLMTEVITJR-WFYBHXQRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Cardiolipin compositions their methods of preparation and use
  申请人：Ahmad U. Moghis

  公开号：US20050181037A1

  公开（公告）日：2005-08-18

  The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.

  本发明提供了一种用于合成不同脂肪酸和/或不同碳链长度以及有或没有不饱和度的磷脂酰肌醇的新合成路线。反应方案可用于生成新形式的磷脂酰肌醇，包括磷脂酰肌醇变异体。通过本方法制备的磷脂酰肌醇可以方便地被纳入脂质体和其他脂质制剂中，这些制剂也可以包括疏水性或亲水性药物等活性剂。这样的制剂可用于治疗疾病或在诊断和/或分析测定中使用。脂质体还可以包括配体，例如用于将其定向到特定细胞类型或组织的配体。
• CARDIOLIPIN COMPOSITIONS, METHODS OF PREPARATION AND USE
  申请人：Neopharm, Inc.

  公开号：EP1513853A2

  公开（公告）日：2005-03-16
• MICROBIAL FERMENTATION-BASED PRODUCTION OF PHOSPHOLIPIDS CONTAINING LONG-CHAIN POLYUNSATURATED FATTY ACIDS AS THEIR CONSTITUENTS
  申请人：SUNTORY LIMITED

  公开号：EP1981982A1

  公开（公告）日：2008-10-22
• PHARMACEUTICAL COMPOSITION AND METHODS
  申请人：Lipocine Inc.

  公开号：EP3185873A1

  公开（公告）日：2017-07-05
• (17-ß)-3-OXOANDROST-4-EN-17-YL UNDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
  申请人：Lipocine Inc.

  公开号：US20160193225A1

  公开（公告）日：2016-07-07

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.