2-ethyl-3-methylmaleic acid | 41654-09-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-ethyl-3-methylmaleic acid
• 英文别名: cis-2-ethyl-3-methylbutenedioic acid；Methyl-ethyl-maleinsaeure；(Z)-2-ethyl-3-methylbut-2-enedioic acid
• CAS: 41654-09-5
• 化学式: C₇H₁₀O₄
• 分子量: 158.154
• InChiKey: HVZKWAQLXHTHSG-PLNGDYQASA-N

物化性质

• 稳定性/保质期：

  存在于烤烟烟叶、白肋烟烟叶、香料烟烟叶中。

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Aspartates containing ketimine-groups and their use in coating compositions
  申请人：Bayer MaterialScience LLC

  公开号：EP1518852A1

  公开（公告）日：2005-03-30

  The present invention relates to novel aspartates, their method of production and the use of these aspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing polyurethane prepolymers. The aspartaes are prepared by first reacting a di- or polyamine with an unsaturated ester and then reacting the resultant product with a ketone.

  本发明涉及新型天冬氨酸盐，其生产方法以及将这些天冬氨酸盐作为双组分聚氨酯涂料组合物中聚异氰酸酯的反应组分和制备聚氨酯预聚物的用途。这些天冬氨酸盐是通过首先将二元或多元胺与不饱和酯反应，然后将所得产物与酮反应制备而成的。
• Metallo-beta-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US20080090825A1

  公开（公告）日：2008-04-17

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  一种新的金属β-内酰胺酶抑制剂，作为一种药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生细菌对β-内酰胺类抗生素的抗菌活性。
• [EN] PHARMACEUTICAL INTERMEDIATES AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] INTERMEDIAIRES PHARMACEUTIQUES ET PROCEDE DE PREPARATION DE CEUX-CI
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2006013399A1

  公开（公告）日：2006-02-09

  The invention relates to pure enantiomer and in certain cases new racemic-isopropanol derivatives of the general Formula (I) and a process for the preparation thereof. The partly new and partly known compounds of the general Formula (I) are useful pharmaceutical intermediates. The substituent definition of symbols R1, R2 and R3 are as stated in the patent specification.

  该发明涉及一种纯对映体，以及通式（I）的某些情况下新的消旋异丙醇衍生物，以及其制备方法。通式（I）的部分新化合物和部分已知化合物是有用的药用中间体。符号R1、R2和R3的取代定义如专利规范中所述。
• [EN] ASPARTATES USEFUL AS COMPONENTS IN COATING COMPOSITIONS AND THEIR PREPARATION<br/>[FR] ASPARTATES UTILISES COMME CONSTITUANTS DANS DES COMPOSITIONS DE REVETEMENT, ET LEUR PREPARATION
  申请人：BAYER MATERIALSCIENCE LLC

  公开号：WO2005073188A1

  公开（公告）日：2005-08-11

  The present invention relates to novel aspartates, their method of production and the use of these aspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing polyurethane prepolymers. The aspartates are prepared by first reacting a di- or polyamine with an unsaturated ester and then reacting the resultant product with a maleimide.

  本发明涉及新颖的天冬氨酸、其制备方法以及将这些天冬氨酸作为双组分聚氨酯涂料组成部分的聚异氰酸酯反应组分和制备聚氨酯预聚体。这些天冬氨酸是通过首先将二元或多元胺与不饱和酯反应，然后将产物与马来酰亚胺反应制备而成。
• METALLO-B-LACTAMASE INHIBITORS
  申请人：MEIJI SEIKA KAISHA, LTD.

  公开号：US20160151322A1

  公开（公告）日：2016-06-02

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式(I)的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式(I)的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。