methyl 3,3-dimethyl-2-(1-phenylethylamino)butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3,3-dimethyl-2-(1-phenylethylamino)butanoate
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: WNSUVIJBKIMHOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl N-(1-phenylethyl)-α-iminoacetate 、 碘代叔丁烷 在 air 、 diethylzinc 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 1.0h， 以66%的产率得到methyl 3,3-dimethyl-2-(1-phenylethylamino)butanoate
  参考文献：
  名称：

  Diethylzinc: A Chain-Transfer Agent in Intermolecular Radical Additions. A Parallel with Triethylborane

  摘要：

  In the presence of oxygen, diethylzinc can be used to promote radical additions to C=N bond containing radical accepters and to enones. In these reactions, it plays at the same time the role of the initiator and the role of the chain-transfer reagent. A parallel with triethylborane-mediated reactions is established. The methodology is restricted to secondary and tertiaryalkyl radicals generated from the corresponding alkyl iodides. It could not be extended either to C=C bond containing radical accepters such as methyl methacrylate and nitrocyclohexene or to diethylazodicarboxylate.

  DOI：

  10.1021/jo9912404

文献信息

• Diethylzinc: A Chain-Transfer Agent in Intermolecular Radical Additions. A Parallel with Triethylborane
  作者：Michèle P. Bertrand、Laurence Feray、Robert Nouguier、P. Perfetti

  DOI：10.1021/jo9912404

  日期：1999.12.1

  In the presence of oxygen, diethylzinc can be used to promote radical additions to C=N bond containing radical accepters and to enones. In these reactions, it plays at the same time the role of the initiator and the role of the chain-transfer reagent. A parallel with triethylborane-mediated reactions is established. The methodology is restricted to secondary and tertiaryalkyl radicals generated from the corresponding alkyl iodides. It could not be extended either to C=C bond containing radical accepters such as methyl methacrylate and nitrocyclohexene or to diethylazodicarboxylate.