(2E,5E)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-pyrrol-2-ylidenepyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (2E,5E)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-pyrrol-2-ylidenepyrrole
• 化学式: C₂₀H₂₅N₃O
• 分子量: 323.4
• InChiKey: WKGQSEFBQTWRPT-FHUUTLRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  49.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] TARGETING P73 FOR CANCERS RESISTANT TO BH3 MIMETICS<br/>[FR] CIBLAGE DE P73 POUR DES CANCERS RÉSISTANTS AUX BH3 MIMÉTIQUES
  申请人：UNIV TEXAS

  公开号：WO2021087177A1

  公开（公告）日：2021-05-06

  Embodiments of the disclosure encompass methods and compositions related to overcoming or preventing cancer resistance to anti-apoptotic proteins, for example BH3 mimetics. The disclosure provides methods for modulating p73 to reduce cancer resistance to BH3 mimetics including inhibitors of Bcl-2, Bcl-xL, Mcl-1, Bcl-W, A1/BFL-1, or a combination thereof. In specific embodiments, targeting isoforms of p73, such as TAp73 or DNp73, results in reduction of cancer resistance to BH3 mimetics to allow effective treatment of hematological cancers.