(5Z)-5-[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-2-phenylimino-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (5Z)-5-[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-2-phenylimino-1,3-thiazolidin-4-one
• 化学式: C₁₈H₁₅ClN₂O₃S
• 分子量: 374.8
• InChiKey: ZBPFQGMWDSAZSA-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods of Treating a Microbial Infection by Modulating RNase-L Expression and/or Activity
  申请人：Hassel Bret A.

  公开号：US20100317677A1

  公开（公告）日：2010-12-16

  The invention relates to methods and compositions for treating a microbial infection. In the present invention, RNase-L activity has been shown to play an integral role in innate immunity and for defense against invading microbes. The present invention is drawn to exploiting the role of RNase-L in innate immunity for methods of treating a microbial infection. The present invention is also drawn to exploiting the role of RNase-L in innate immunity for methods of treating an immune related disease or disorder.
• [EN] ANTI-VIRAL AGENTS THAT ACTIVATE RNASE L<br/>[FR] AGENTS ANTI-VIRAUX QUI ACTIVENT L'ARNSE L
  申请人：CLEVELAND CLINIC FOUNDATION

  公开号：WO2007127212A2

  公开（公告）日：2007-11-08

  [EN] RNase L Activators and methods of using the same are disclosed herein.
  [FR] L'invention concerne des activateurs d'ARNse L et des méthodes pour les utiliser.