[(E)-octadec-9-enyl] 2,3-dihydroxypropanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: [(E)-octadec-9-enyl] 2,3-dihydroxypropanoate
• 化学式: C₂₁H₄₀O₄
• 分子量: 356.5
• InChiKey: JPJYKWFFJCWMPK-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  25
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions and methods for delivery of biologically active agents
  申请人：Khoo Shui-Mei

  公开号：US20070108405A1

  公开（公告）日：2007-05-17

  The present invention provides methods and compositions for the delivery of a biologically active agent to a biological system. The compositions include the active agent and a lyotropic phase and release of the active agent to the biological system is modified by the lyotropic phase.

  本发明提供了将生物活性物质传递到生物系统的方法和组合物。这些组合物包括活性物质和亲疏水相，而亲疏水相可以调节活性物质在生物系统中的释放。
• Urea-, glycerate- and, hydroxyamide-headed hydrocarbon chain lyotropic phases forming surfactants
  申请人：Boyd James Benjamin

  公开号：US20050249665A1

  公开（公告）日：2005-11-10

  The invention provides a compound containing a head group based on urea, glycerol or glycerate and a tail selected from the group consisting of a branched alkyl chain, a branched alkyloxy chain or an alkenyl chain. The compounds may be used as surfactants to form a lyotropic phase that is stable in excess polar solution.

  本发明提供了一种化合物，其头部基团为尿素、甘油或甘油酸酯，尾部基团选自支链烷基、支链烷氧基或烯基。这些化合物可用作表面活性剂，形成在过量极性溶液中稳定的溶解相。
• COMPOSITIONS AND METHODS FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS
  申请人：FH Faulding & Co. Limited

  公开号：EP1667656A1

  公开（公告）日：2006-06-14
• MODIFIED RELEASE DRUG POWDER COMPOSITION COMPRISING GASTRO-RETENTIVE RAFT FORMING SYSTEMS HAVING TRIGGER PULSE DRUG RELEASE
  申请人：Tris Pharma, Inc.

  公开号：US20220241189A1

  公开（公告）日：2022-08-04

  An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS<br/>[FR] COMPOSITIONS ET PROCEDES POUR LA DELIVRANCE D'AGENTS BIOLOGIQUEMENT ACTIFS
  申请人：DBL AUSTRALIA PTY LTD

  公开号：WO2005021046A1

  公开（公告）日：2005-03-10

  The present invention provides methods and compositions for the delivery of a biologically active agent to a biological system. The compositions include the active agent and a lyotropic phase and release of the active agent to the biological system is modified by the lyotropic phase.