1-trideuteromethoxymethyluracil

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-trideuteromethoxymethyluracil
• 化学式: C₆H₈N₂O₃
• 分子量: 159.117
• InChiKey: JCFPRDZTQIDTMH-FIBGUPNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.86
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.09
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-(2,4-二氧代嘧啶-1-基)乙酸 、 甲醇-d3 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成 1-trideuteromethoxymethyluracil
  参考文献：
  名称：

  Anodic decarboxylative oxidation of carboxymethyluracil and -thymine isomers

  摘要：

  The anodic oxidative decarboxylation of isomers of uracil and thymine acetic acids was studied. Electrolysis in methanolic or ethanolic solutions yielded respective alkoxymethyl derivatives via carbocationic intermediates. In acetic acid/sodium acetate medium, these were trapped by acetate, resulting in corresponding acetoxymethyl derivatives. Electrolysis in fully deuterated methanol or deuterated acetic acid, allow to obtain respective trideuterated compounds. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(96)01151-9

文献信息

• Anodic decarboxylative oxidation of carboxymethyluracil and -thymine isomers
  作者：Jaroslaw Kamiński、Maria Pachulska、Ryszard Stolarski、Zygmunt Kazimierczuk

  DOI：10.1016/s0040-4020(96)01151-9

  日期：1997.2

  The anodic oxidative decarboxylation of isomers of uracil and thymine acetic acids was studied. Electrolysis in methanolic or ethanolic solutions yielded respective alkoxymethyl derivatives via carbocationic intermediates. In acetic acid/sodium acetate medium, these were trapped by acetate, resulting in corresponding acetoxymethyl derivatives. Electrolysis in fully deuterated methanol or deuterated acetic acid, allow to obtain respective trideuterated compounds. (C) 1997, Elsevier Science Ltd.