((10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)dimethyl(phenyl)silane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ((10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)dimethyl(phenyl)silane
• 英文别名: (((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)dimethyl(phenyl)silane；[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy-dimethyl-phenylsilane
• 化学式: C₃₅H₅₆OSi
• 分子量: 520.915
• InChiKey: RSCPLTNJSGPULZ-XMKBYUECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.53
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二甲基苯基硅烷 、 benzyl 3-cholesteryl ether 在 dicobalt octacarbonyl 、 一氧化碳 作用下， 以 苯 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 50.5h， 以76%的产率得到((10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)dimethyl(phenyl)silane
  参考文献：
  名称：

  裂解苯甲醚的活性钴催化剂

  摘要：

  描述了一种在Me 2 PhSiH和CO（1 atm）存在下使用催化量的Co 2（CO）8脱除苄基醚的改进方法。脱保护反应与双键或含硫底物相容。该方法还可以耐受其他官能团，例如Ac，Piv和Bz，并在过苄基单糖中显示出潜在的选择性。

  DOI：

  10.1021/jo2018284

文献信息

• Activation of silanes by Grubbs’ carbene complex Cl2(PCy3)2RuCHPh: dehydrogenative condensation of alcohols and hydrosilylation of carbonyls
  作者：Sarah V Maifeld、Reagan L Miller、Daesung Lee

  DOI：10.1016/s0040-4039(02)01385-0

  日期：2002.9

  This manuscript describes two catalytic methods for silyl ether synthesis using Grubbs’ catalyst Cl2(PCy3)2RuCHPh. Silyl ethers are obtained from the reaction of a variety of silanes with alcohols by dehydrogenative condensation and by the hydrosilylation of carbonyl compounds. Both reactions occur under neat conditions.

  这个手稿描述了使用Grubbs催化剂Cl作为甲硅烷基醚的合成两个催化方法2（PCY 3）2 RuCHPh。甲硅烷基醚是由各种硅烷与醇通过脱氢缩合反应和羰基化合物的氢化硅烷化反应制得的。两种反应均在纯净条件下发生。
• Iron‐Catalyzed Alkoxylation, Dehydrogenative‐Polymerization and Tandem Hydrosilylative‐Alkoxylation
  作者：Anirban Sen、Rohit Kumar、Tanuja Tewari、Rajesh G. Gonnade、Samir H. Chikkali

  DOI：10.1002/chem.202301375

  日期：2023.8.25

  Construction of Si−O−C bond has been the monopoly of precious, rare, late transition metal catalysts. Reported here is a molecularly defined iron complex that catalyzes alkoxylation, dehydrogenative polymerization and tandem hydrosilylative-alkoxylation with only H2 as the byproduct. The iron catalyst tolerates an array of alcohols, silanes and produces Si−O coupled product under mild conditions with

  Si−O−C 键的构建一直是贵重、稀有、后过渡金属催化剂的垄断。本文报道了一种分子定义的铁络合物，其催化烷氧基化、脱氢聚合和串联氢化硅烷化-烷氧基化，仅产生H 2作为副产物。该铁催化剂能耐受一系列醇、硅烷，并在温和条件下以优异的产率产生 Si−O 偶联产物。
• Active Cobalt Catalyst for the Cleavage of Benzyl Ether
  作者：Bo Wang、Zhaojun Yin、Yangbing Li、Ting-Xiang Yang、Xiang-Bao Meng、Zhong-Jun Li

  DOI：10.1021/jo2018284

  日期：2011.11.18

  An improved method for the deprotection of benzyl ethers using a catalytic amount of Co2(CO)8 in the presence of Me2PhSiH and CO (1 atm) is described. The deprotection reaction is compatible with double bond or sulfur-containing substrates. The method also tolerates other functional groups, such as Ac, Piv, and Bz, and shows potential selectivity in perbenzylated monosaccharides.

  描述了一种在Me 2 PhSiH和CO（1 atm）存在下使用催化量的Co 2（CO）8脱除苄基醚的改进方法。脱保护反应与双键或含硫底物相容。该方法还可以耐受其他官能团，例如Ac，Piv和Bz，并在过苄基单糖中显示出潜在的选择性。