MK-32

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: MK-32
• 英文别名: (2R)-5-(diaminomethylideneamino)-2-(1H-indol-3-ylmethylamino)pentanoic acid
• 化学式: C₁₅H₂₁N₅O₂
• 分子量: 303.364
• InChiKey: KCCJNGICTCRAKO-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  130
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲酰基吲哚酸-1-羧酸 t-丁基酯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 MK-32
  参考文献：
  名称：

  N -Alkylaminoacids and Their derivatives interact with melanocortin receptors

  摘要：

  Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC1,3-5 reaching the low micromolar range. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00089-6

文献信息

• N -Alkylaminoacids and Their derivatives interact with melanocortin receptors
  作者：Felikss Mutulis、Ilze Mutule、Jarl E.S. Wikberg

  DOI：10.1016/s0960-894x(02)00089-6

  日期：2002.4

  Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC1,3-5 reaching the low micromolar range. (C) 2002 Elsevier Science Ltd. All rights reserved.