disodium;(3Z)-3-[[4-(2-carboxylatoethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: disodium;(3Z)-3-[[4-(2-carboxylatoethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate
• 化学式: C17H13N3Na2O6
• 分子量: 401.28
• InChiKey: GNDOBTSWAIDUCE-OVVGNOJWSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -7.85
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  151
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Therapeutic approaches for treating CMT and related disorders
  申请人：PHARNEXT

  公开号：US10322101B2

  公开（公告）日：2019-06-18

  Compositions and methods for the treatment of Charcot-Marie-Tooth disease and related disorders. Also provided are combination therapies for treating this disease by decreasing PMP22 expression in a subject.

  治疗夏科-玛丽-牙病及相关疾病的组合物和方法。此外，还提供了通过降低受试者体内 PMP22 表达来治疗该疾病的组合疗法。
• NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY
  申请人：Oy Jurilab Ltd

  公开号：EP2021502A1

  公开（公告）日：2009-02-11
• NEW THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS
  申请人：Pharnext

  公开号：EP2211846A1

  公开（公告）日：2010-08-04
• New therapeutic approaches for treating CMT and related disorders
  申请人：Pharnext

  公开号：EP2211846B1

  公开（公告）日：2013-02-27
• THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS
  申请人：Cohen Daniel

  公开号：US20100310641A1

  公开（公告）日：2010-12-09

  The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject.