NapSul-Ile-Trp-CHO

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: NapSul-Ile-Trp-CHO
• 英文别名: (2S)-N-[(2S)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-3-methyl-2-(naphthalen-1-ylsulfonylamino)pentanamide
• 化学式: C₂₇H₂₉N₃O₄S
• 分子量: 491.611
• InChiKey: FFPHAWVFZQFOJA-PSHWQTJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Production of aldehyde derivatives
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0731107A1

  公开（公告）日：1996-09-11

  This invention relates to a method for producing a compound of the formula (II) wherein R1, R2 and R3 independently represent hydrogen or a hydrocarbon group that may be substituted; R4 represents acyl; m and n are independently 0 or 1 or a salt thereof, which comprises subjecting a compound of the formula (I) wherein R1, R2, R3, R4, m and n are as defined above; R5 and R6 independently represent a hydrocarbon group that may be substituted; or a salt thereof to a reduction reaction, by which the objective compound can be obtained under mild conditions and in good yield.

  本发明涉及一种制备式（II）化合物的方法，其中R1、R2和R3分别代表氢或可能被取代的碳氢基团；R4代表酰基；m和n分别独立地为0或1或其盐，该方法包括将式（I）化合物进行还原反应，其中R1、R2、R3、R4、m和n如上所定义；R5和R6分别代表可能被取代的碳氢基团或其盐，从而在温和条件下且产率良好地获得所需的化合物。
• Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0611756A2

  公开（公告）日：1994-08-24

  The present invention provides a cathepsin L inhibitor containing a compound of the formula: wherein R¹ is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R² and R³ independently are a hydrogen atom or a hydrocarbon residue which may be substituted; R⁴ is an alkanoyl, sulfonyl, carbonyloxy, carbamoyl or thiocarbamoyl group which may be substituted; X is formula: -CHO or -CH₂OB (wherein B is a hydrogen atom or a protecting group of hydroxyl group); m and n independently are an integer of 0 or 1; provided that R⁴ is an alkanoyl group substituted by aryl, a sulfonyl group substituted by aryl having more than 9 carbon atoms or by lower alkyl, or a carbamoyl or thiocarbamoyl group which may be substituted when R¹ is an unsubstituted lower alkyl, arylalkyl on methylthioethyl group, R² and R³ independently are a lower alkyl or arylalkyl, X is -CHO, m is 1 and n is 0 or 1, or a salt thereof. Compound (I) is useful as a prophylactic/therapeutic agent for osteoporosis.

  本发明提供了一种含有式化合物的凝血酶 L 抑制剂： 其中，R¹为氢原子或可被取代的芳烷基、杂环烷基或低级烷基；R²和R³各自为氢原子或可被取代的烃残基；R⁴为可被取代的烷酰基、磺酰基、羰氧基、氨基甲酰基或硫代氨基甲酰基；X为式：-CHO或-CH₂OB（其中 B 为氢原子或羟基保护基团）；m 和 n 分别为 0 或 1 的整数；条件是 R⁴ 是被芳基取代的烷酰基、被具有 9 个以上碳原子的芳基或低级烷基取代的磺酰基、或当 R¹ 是未取代的低级烷基、芳烷基或甲硫基时可能被取代的氨基甲酰基或硫代氨基甲酰基，R² 和 R³ 独立地是低级烷基或芳烷基，X 是 -CHO，m 是 1，n 是 0 或 1，或其盐。 化合物 (I) 可用作骨质疏松症的预防/治疗剂。
• Targeting CAPN9/CAPNS2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
  申请人：The Johns Hopkins University

  公开号：US11219670B2

  公开（公告）日：2022-01-11

  Provided herein are, inter alia, compositions and methods for identifying and using agents capable of inhibiting myofibroblast transition as well as methods for treating diseases associated with the same in a subject in need thereof.

  本文特别提供了用于鉴定和使用能够抑制肌成纤维细胞转化的制剂的组合物和方法，以及用于治疗与之相关的疾病的方法。
• JPH07101924A
  申请人：——

  公开号：JPH07101924A

  公开（公告）日：1995-04-18
• JPH08283221A
  申请人：——

  公开号：JPH08283221A

  公开（公告）日：1996-10-29