diisobutyl-malonic acid dimethyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diisobutyl-malonic acid dimethyl ester
• 英文别名: Diisobutyl-malonsaeure-dimethylester；Dimethyl 2,2-diisobutylmalonate；dimethyl 2,2-bis(2-methylpropyl)propanedioate
• 化学式: C₁₃H₂₄O₄
• 分子量: 244.331
• InChiKey: VMSDGXIKDYLSHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diisobutyl-malonic acid dimethyl ester 在 氢氧化钾 作用下， 生成 2,2-Bis(2-methylpropyl)propanedioic acid
  参考文献：
  名称：

  Marshall, Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 234

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁基丙二酸二甲酯 生成 diisobutyl-malonic acid dimethyl ester
  参考文献：
  名称：

  Marshall, Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 234

  摘要：

  DOI：

文献信息

• Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle
  作者：A Choppin、R M Eglen

  DOI：10.1038/sj.bjp.0704165

  日期：2001.8

  The pharmacological characteristics of muscarinic receptors in the male mice urinary bladder smooth muscle were studied. (+)‐Cis‐dioxolane, oxotremorine‐M, acetylcholine, carbachol and pilocarpine induced concentration‐dependent contractions of the urinary bladder smooth muscle (pEC50=6.6±0.1, 6.9±0.1, 6.7±0.1, 5.8±0.1 and 5.8±0.1, EMax=3.2±0.8 g, 2.7±0.4 g, 1.0±0.1 g, 2.7±0.3 and 0.9±0.2 g, respectively, n=4). These contractions were competitively antagonized by a range of muscarinic receptor antagonists (pKB values): atropine (9.22±0.09), pirenzepine (6.85±0.08), 4‐DAMP (8.42±0.14), methoctramine (5.96±0.05), p‐F‐HHSiD (7.48±0.09), tolterodine (8.89±0.13), AQ‐RA 741 (7.04±0.12), s‐secoverine (8.21±0.09), zamifenacin (8.30±0.17) and darifenacin (8.70±0.09). In this tissue, the pKB values correlated most favourably with pKi values for these compounds at human recombinant muscarinic M3 receptors. A significant correlation was also noted at human recombinant muscarinic m5 receptors given the poor discriminative ability of ligands between M3 and m5 receptors. In recontraction studies, in which the muscarinic M3 receptor population was decreased, and conditions optimized to study M2 receptor activation, methoctramine exhibited an affinity estimate consistent with muscarinic M3 receptors (pKB=6.23±0.14; pA2=6.16±0.03). Overall, these data study suggest that muscarinic M3 receptors are the predominant, if not the exclusive, subtype mediating contractile responses to muscarinic agonists in male mouse urinary bladder smooth muscle. British Journal of Pharmacology (2001) 133, 1035–1040; doi:10.1038/sj.bjp.0704165

  以下为将文本翻译成中文后的版本： < Jays 列表列表类型="明确标签"> < Jays 列表项> 雄性小鼠膀胱平滑肌中毒蕈碱受体的药理学特性进行了研究。 < Jays 列表项> (+)‐Cis‐dioxolane, oxotremorine‐M, acetylcholine, carbachol 和 pilocarpine 引起膀胱平滑肌浓度依赖性收缩（pEC < Jays 子> 50 =6.6±0.1, 6.9±0.1, 6.7±0.1, 5.8±0.1 和 5.8±0.1, E < Jays 子> max =3.2±0.8 g, 2.7±0.4 g, 1.0±0.1 g, 2.7±0.3 和 0.9±0.2 g, 分别，n=4）。这些收缩作用被一系列毒蕈碱受体拮抗剂竞争性拮抗（pK < Jays 子> B 值）：atropine（9.22±0.09），pirenzepine（6.85±0.08），4‐DAMP（8.42±0.14），methoctramine（5.96±0.05），p‐F‐HHSiD（7.48±0.09），tolterodine（8.89±0.13），AQ‐RA 741（7.04±0.12），s‐secoverine（8.21±0.09），zamifenacin（8.30±0.17）和 darifenacin（8.70±0.09）。 < Jays 列表项> 在此组织中，pK < Jays 子> B 值与这些化合物在人源重组毒蕈碱 M < Jays 子> 3 受体上的 pK < Jays 子> i 值相关性最好。在人源重组毒蕈碱 m5 受体上也观察到显著相关性，因配体在 M < Jays 子> 3 和 m5 受体之间区分能力有限。 < Jays 列表项> 在重新收缩研究中，毒蕈碱 M < Jays 子> 3 受体群减少，并优化条件以研究 M < Jays 子> 2 受体激活时，methoctramine 的亲和力估计值与毒蕈碱 M < Jays 子> 3 受体一致（pK < Jays 子> B =6.23±0.14；pA < Jays 子> 2 =6.16±0.03）。 < Jays 列表项> 总体而言，这些数据研究表明，毒蕈碱 M < Jays 子> 3 受体是介导雄性小鼠膀胱平滑肌对毒蕈碱激动剂收缩反应的主要亚型，如果不是唯一的。 < Jays 突体> 英国药理学杂志 (2001) < Jays 粗体> 133 , 1035–1040; doi: < Jays 扩展链接 xmlns:xlink="http://www.w3.org/1999/xlink" 扩展链接类型="doi" xlink:href="10.1038/sj.bjp.0704165"> 10.1038/sj.bjp.0704165 希望这段翻译对您有所帮助！
• Alkoxymagnesium, method for producing alkoxymagnesium, solid catalyst component for olefin polymerization, olefin polymerization catalyst, and method for producing olefin polymer
  申请人：TOHO TITANIUM CO., LTD.

  公开号：US11008408B2

  公开（公告）日：2021-05-18

  There is provided a novel alkoxymagnesium which, when used as a constituent of a solid catalyst component for olefin polymerization to polymerize an olefin, may reduce the formation rate of a fine powder and may form a polymer having an excellent particle size distribution under high polymerization activity. The alkoxymagnesium is characterized by comprising secondary particles each of which is an aggregate of primary particles having an average particle diameter of less than 1 μm and by having a ratio represented by the average particle diameter of the primary particles/the average particle diameter of the secondary particles of 0.1 or less, a total pore volume of 0.5 to 1 cm3/g, a specific surface area of less than 50 m2/g, and a particle size distribution index (SPAN) 1 or less.

  提供了一种新型的烷氧基镁，当用作固体催化剂组分的成分之一，用于聚合烯烃以聚合烯烃时，可以降低细粉末形成速率，并在高聚合活性下形成具有优异粒径分布的聚合物。该烷氧基镁的特征在于包含次级颗粒，每个次级颗粒是小于1μm的原颗粒聚集体，并且具有由原颗粒的平均粒径/次级颗粒的平均粒径表示的比率为0.1或以下，总孔体积为0.5至1 cm3/g，比表面积小于50 m2/g，粒径分布指数（SPAN）为1或以下。
• OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20130109789A1

  公开（公告）日：2013-05-02

  An olefin polymerization catalyst is obtained by bringing the following components (A), (B) and (C) into contact with one another: (A) a solid catalyst component for olefin polymerization containing a titanium atom, a magnesium atom and a halogen atom; (B) an organoaluminum compound; and (C) a triether represented by formula (I). An olefin polymerization solid catalyst can be provided having a sufficiently high polymerization activity and an ability to produce an olefin polymer with a low content of low-molecular weight components and amorphous components.

  一种烯烃聚合催化剂是通过将以下组分（A）、（B）和（C）彼此接触而获得的：（A）用于烯烃聚合的固体催化剂组分，其中包含钛原子、镁原子和卤素原子；（B）有机铝化合物；以及（C）由式（I）表示的三醚。可以提供具有足够高的聚合活性和能够产生低分子量成分和非晶态成分含量低的烯烃聚合物的固体聚合催化剂。
• SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Uozumi Toshiya

  公开号：US20140221583A1

  公开（公告）日：2014-08-07

  An olefin polymer that is obtained using an olefin polymerization catalyst that includes a solid catalyst component for olefin polymerization that includes titanium, magnesium, a halogen, and an ester compound (A) represented by the following formula (1): R 1 R 2 C═C(COOR 3 )(COOR 4 ), an organoaluminum compound, and an optional external electron donor compound, exhibits primary properties (e.g., molecular weight distribution and stereoregularity) similar to those of an olefin polymer obtained using a solid catalyst component that includes a phthalic ester as an electron donor.

  使用一种包括钛、镁、卤素和酯化合物(A)的固体催化剂组分（式子1：R1R2C═C(COOR3)(COOR4)）进行烯烃聚合得到的烯烃聚合物，加上有机铝化合物和可选的外部电子给体化合物，表现出与包括邻苯二甲酸酯作为电子给体的固体催化剂组分得到的烯烃聚合物相似的主要性质（如分子量分布和立构规则性）。
• SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME
  申请人：Toho Titanium CO., LTD.

  公开号：EP2360190A1

  公开（公告）日：2011-08-24

  A solid catalyst component for olefin polymerization is produced by causing (a) a solid component that includes magnesium, titanium, a halogen, and an electron donor, (b) an aminosilane compound shown by the following general formula (1), and (c) at least one organosilicon compound selected from an organosilicon compound shown by the following general formula (2-A) and an organosilicon compound shown by the following general formula (2-B) to come in contact with each other. A polymer having high stereoregularity is produced in high yield while achieving a high melt flow rate due to hydrogen by polymerizing an olefin in the presence of a catalyst that includes the solid catalyst component.         R1nSi(NR2R3)4-n     (1)         [CH2=CH-(CH2)1]qSiR44-q     (2-A)         R5Si(OR6)4-s     (2-B)

  一种用于烯烃聚合的固体催化剂组分是通过使(a)一种包括镁、钛、卤素和电子供体的固体组分，(b)如下通式(1)所示的氨基硅烷化合物，和(c)至少一种选自如下通式(2-A)所示的有机硅化合物和如下通式(2-B)所示的有机硅化合物的有机硅化合物相互接触而制得的。在含有固体催化剂组分的催化剂存在下，通过聚合烯烃，可以高产率地生产出具有高立体规整度的聚合物，同时由于氢气的存在，可以达到较高的熔体流动速率。 R1nSi(NR2R3)4-n (1) [CH2=CH-(CH2)1]qSiR44-q (2-A) R5Si(OR6)4-s (2-B)