1-benzyl-3-[4-(9H-fluoren-9-yl)-1-piperazinyl]-2,5-pyrrolidinedione

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 1-benzyl-3-[4-(9H-fluoren-9-yl)-1-piperazinyl]-2,5-pyrrolidinedione
• 化学式: C₂₈H₂₇N₃O₂
• 分子量: 437.541
• InChiKey: LQAREJYXWYWJFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33.0
• 可旋转键数：
  4.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  43.86
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  N-苄基马来酰亚胺 、 1-(9H-芴-9-基)-哌嗪 在 lithium perchlorate trihydrate 作用下， 以 1,4-二氧六环 为溶剂， 以83%的产率得到1-benzyl-3-[4-(9H-fluoren-9-yl)-1-piperazinyl]-2,5-pyrrolidinedione
  参考文献：
  名称：

  Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis

  摘要：

  In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against Mycobacterium tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.10.069

文献信息

• Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis
  作者：Tetiana Matviiuk、Giorgia Mori、Christian Lherbet、Frédéric Rodriguez、Maria Rosalia Pasca、Marian Gorichko、Brigitte Guidetti、Zoia Voitenko、Michel Baltas

  DOI：10.1016/j.ejmech.2013.10.069

  日期：2014.1

  In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against Mycobacterium tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA. (C) 2013 Elsevier Masson SAS. All rights reserved.