Cbz-O-succinate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Cbz-O-succinate
• 英文别名: 4-Oxo-4-phenylmethoxycarbonyloxybutanoic acid
• 化学式: C₁₂H₁₂O₆
• 分子量: 252.224
• InChiKey: MEBHISPNBWJYDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Cbz-O-succinate 在 碳酸氢钠 、 三氟乙酸 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成 ((S)-3-Benzyl-3-benzyloxycarbonylamino-2-oxo-azepan-1-yl)-acetic acid
  参考文献：
  名称：

  Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3P4 quaternary lactam dipeptide surrogates

  摘要：

  SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design of series 2a-g, featuring quaternary alpha-amino-alpha-benzyl-lactam scaffolds that serve as novel P-3-P-4 dipeptide mimics. The design, synthesis, and biological activity of these targets are presented. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00446-0

文献信息

• ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
  申请人：Goldblum Adam Aaron

  公开号：US20120122809A1

  公开（公告）日：2012-05-17

  Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q 1 and Q 2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  揭示了具有抗菌活性的化合物。这些化合物具有以下结构（I）：包括立体异构体、前药和其药用可接受的盐，其中Q1和Q2如本文所定义。还公开了与制备和使用这些化合物相关的方法，以及包含这些化合物的药物组合物。
• [EN] OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION<br/>[FR] CONJUGUÉS LIGANDS D'OLIGONUCLÉOTIDES ET PROCÉDÉ POUR LEUR PRÉPARATION
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2015006740A3

  公开（公告）日：2015-05-07
• Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3P4 quaternary lactam dipeptide surrogates
  作者：J.Edward Semple、Nathaniel K. Minami、Susan Y. Tamura、Terence K. Brunck、Ruth F. Nutt、William C. Ripka

  DOI：10.1016/s0960-894x(97)00446-0

  日期：1997.9

  SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design of series 2a-g, featuring quaternary alpha-amino-alpha-benzyl-lactam scaffolds that serve as novel P-3-P-4 dipeptide mimics. The design, synthesis, and biological activity of these targets are presented. (C) 1997 Elsevier Science Ltd.