N,N'-dimethylethylenediamine bis(methanesulfonic acid)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N,N'-dimethylethylenediamine bis(methanesulfonic acid)
• 英文别名: N,N'-dimethylethane-1,2-diamine;methanesulfonic acid
• 化学式: 2CH₄O₃S*C₄H₁₂N₂
• 分子量: 280.367
• InChiKey: DMQKLCBQHMATNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.07
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  86.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲烷磺酸 、 N,N'-二甲基乙二胺 以 乙醇 为溶剂， 反应 0.33h， 以73%的产率得到N,N'-dimethylethylenediamine bis(methanesulfonic acid)
  参考文献：
  名称：

  A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

  摘要：

  A stable adduct of Cul with Bu4NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C-N and C-O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results.

  DOI：

  10.1021/jo300905w
• 作为试剂：
  描述：

  2-吡咯烷酮 、 1,3-二甲基-5-碘苯 在 bis(tetrapropylammonium) tetraiododicuprate(I) 、 N,N'-dimethylethylenediamine bis(methanesulfonic acid) 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以88%的产率得到1-(3,5-dimethylphenyl)-1H-pyrrolidin-2-one
  参考文献：
  名称：

  A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

  摘要：

  A stable adduct of Cul with Bu4NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C-N and C-O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results.

  DOI：

  10.1021/jo300905w