1,3-bis(dimethylmaleimido)propane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,3-bis(dimethylmaleimido)propane
• 英文别名: 1-[3-(3,4-Dimethyl-2,5-dioxopyrrol-1-yl)propyl]-3,4-dimethylpyrrole-2,5-dione
• 化学式: C₁₅H₁₈N₂O₄
• 分子量: 290.319
• InChiKey: YSRFFEOXDDYJCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-bis(dimethylmaleimido)propane 在 二苯甲酮 作用下， 以 丙酮 、 乙腈 为溶剂， 反应 20.0h， 以65%的产率得到1,6-diaza-3,4,8,9-tetramethyltetracyclo[4.4.3.0^3,9.0^4,8]trideca-2,5,7,10-tetraone
  参考文献：
  名称：

  Synthesis of cis,cis,cis-Tetrasubstituted Cyclobutanes. Trapping of Tetrahedral Intermediates in Intramolecular Nucleophilic Addition

  摘要：

  The intramolecular [2 + 2] photocycloaddition of bismaleimides leads to cage diimides 2. Nucleophilic addition on these compounds (NaBH4, RLi, or MeONa) gives rise to various diazatetracyclic 4 and 11 or oxadiazapentacyclic 3 "bowl shaped" alcohols. X-ray analyses of 3c and 11a provide definite structural data concerning these two highly functionalized compounds.

  DOI：

  10.1021/jo000361x
• 作为产物：
  描述：

  2,3-二甲基马来酸酐 、 1,3-丙二胺 以 甲苯 为溶剂， 反应 2.0h， 以60%的产率得到1,3-bis(dimethylmaleimido)propane
  参考文献：
  名称：

  Synthesis of cis,cis,cis-Tetrasubstituted Cyclobutanes. Trapping of Tetrahedral Intermediates in Intramolecular Nucleophilic Addition

  摘要：

  The intramolecular [2 + 2] photocycloaddition of bismaleimides leads to cage diimides 2. Nucleophilic addition on these compounds (NaBH4, RLi, or MeONa) gives rise to various diazatetracyclic 4 and 11 or oxadiazapentacyclic 3 "bowl shaped" alcohols. X-ray analyses of 3c and 11a provide definite structural data concerning these two highly functionalized compounds.

  DOI：

  10.1021/jo000361x

文献信息

• US8815980B2
  申请人：——

  公开号：US8815980B2

  公开（公告）日：2014-08-26
• Synthesis of <i>cis,cis,cis</i>-Tetrasubstituted Cyclobutanes. Trapping of Tetrahedral Intermediates in Intramolecular Nucleophilic Addition
  作者：Dorothée Laurenti、Christiane Santelli-Rouvier、Gérard Pèpe、Maurice Santelli

  DOI：10.1021/jo000361x

  日期：2000.10.1

  The intramolecular [2 + 2] photocycloaddition of bismaleimides leads to cage diimides 2. Nucleophilic addition on these compounds (NaBH4, RLi, or MeONa) gives rise to various diazatetracyclic 4 and 11 or oxadiazapentacyclic 3 "bowl shaped" alcohols. X-ray analyses of 3c and 11a provide definite structural data concerning these two highly functionalized compounds.