N'-[(E)-(1,2-dimethyl-1H-indol-3-yl)methylidene]naphtho[2,1-b]furan-2-carbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: N'-[(E)-(1,2-dimethyl-1H-indol-3-yl)methylidene]naphtho[2,1-b]furan-2-carbohydrazide
• 英文别名: N-[(E)-(1,2-dimethylindol-3-yl)methylideneamino]benzo[e][1]benzofuran-2-carboxamide
• 化学式: C₂₄H₁₉N₃O₂
• 分子量: 381.4
• InChiKey: UUAWRQYBCNIEBR-AFUMVMLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING N-METHYLENENAPHTHO[2,1-b]FURAN-2-CARBOHYDRAZIDE DERIVATIVES AS AN ACTIVE INGREDIENT
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20150182502A1

  公开（公告）日：2015-07-02

  The present invention relates to ethyl(2-methyl-3(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
• ANTI-INFLAMMATORY COMPOSITION COMPRISING ACYLHYDRAZONE DERIVATIVE
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20210030716A1

  公开（公告）日：2021-02-04

  The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.
• US9433607B2
  申请人：——

  公开号：US9433607B2

  公开（公告）日：2016-09-06