ethyl 2-isobutoxy-4-methylbenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-isobutoxy-4-methylbenzoate
• 英文别名: Ethyl 4-methyl-2-(2-methylpropoxy)benzoate；ethyl 4-methyl-2-(2-methylpropoxy)benzoate
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: QGLPPMSVUHOBTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-isobutoxy-4-methylbenzoate 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 16.0h， 以98%的产率得到ethyl 4-(bromomethyl)-2-isobutoxybenzoate
  参考文献：
  名称：

  [EN] SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS
  [FR] COMPOSÉS TRICYCLIQUES SUBSTITUÉS POSSÉDANT UNE ACTIVITÉ CONTRE LES RÉCEPTEURS EP1

  摘要：

  本发明属于EP1受体配体领域。更具体地，它涉及具有对EP1受体具有很高亲和力和选择性的一般式(I)化合物。该发明还涉及它们的制备方法，以及它们作为药物用于治疗和/或预防由EP1受体介导的疾病或紊乱，以及包含它们的药物组合物。

  公开号：

  WO2013149997A1
• 作为产物：
  描述：

  4-甲基水杨酸 在 硫酸 、 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 32.0h， 生成 ethyl 2-isobutoxy-4-methylbenzoate
  参考文献：
  名称：

  [EN] SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS
  [FR] COMPOSÉS TRICYCLIQUES SUBSTITUÉS POSSÉDANT UNE ACTIVITÉ CONTRE LES RÉCEPTEURS EP1

  摘要：

  本发明属于EP1受体配体领域。更具体地，它涉及具有对EP1受体具有很高亲和力和选择性的一般式(I)化合物。该发明还涉及它们的制备方法，以及它们作为药物用于治疗和/或预防由EP1受体介导的疾病或紊乱，以及包含它们的药物组合物。

  公开号：

  WO2013149997A1

文献信息

• Internal donor structure for olefin polymerization catalysts and methods of making and using same
  申请人：W.R. Grace & Co.-Conn.

  公开号：US10144790B2

  公开（公告）日：2018-12-04

  The presently disclosed and claimed inventive concept(s) relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound having at least one ester group and at least one alkoxy group, and catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The presently disclosed and claimed inventive concept(s) further relates to methods of making the catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

  本发明公开和要求的发明概念涉及固体催化剂组分，包括钛、镁、卤素和具有至少一个酯基和至少一个烷氧基的内部电子供体化合物，以及含有催化剂固体组分、有机铝化合物和有机硅化合物的催化剂体系。本公开和权利要求的发明概念进一步涉及制造催化剂组分和催化剂体系的方法，以及使用催化剂体系聚合或共聚α-烯烃的方法。
• Internal Donor Structure for Olefin Polymerization Catalysts and Methods of Making and Using Same
  申请人：Chang Main

  公开号：US20130137568A1

  公开（公告）日：2013-05-30

  The presently disclosed and claimed inventive concept(s) relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound having at least one ester group and at least one alkoxy group, and catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The presently disclosed and claimed inventive concept(s) further relates to methods of making the catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.
• NEW INTERNAL DONORS FOR ETHYLENE POLYMERIZATION CATALYSTS AND METHODS OF MAKING AND USING SAME II
  申请人：BASF CORPORATION

  公开号：US20130231447A1

  公开（公告）日：2013-09-05

  Solid catalyst components are disclosed including titanium, magnesium, halogen and an internal electron donor compound having at least one ester group and at least one alkoxy group, and catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. Further, methods of making the catalyst components and the catalyst systems are disclosed as well as methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.
• INTERNAL DONOR STRUCTURE FOR OLEFIN POLYMERIZATION CATALYSTS AND METHODS OF MAKING AND USING SAME
  申请人：BASF Corporation

  公开号：US20140235805A1

  公开（公告）日：2014-08-21

  The presently disclosed and claimed inventive concept(s) relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound having at least one ester group and at least one alkoxy group, and catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The presently disclosed and claimed inventive concept(s) further relates to methods of making the catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.
• US8765626B2
  申请人：——

  公开号：US8765626B2

  公开（公告）日：2014-07-01