(6Z,9E,12E)-octadeca-6,9,12-trien-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (6Z,9E,12E)-octadeca-6,9,12-trien-1-ol
• 化学式: C₁₈H₃₂O
• 分子量: 264.4
• InChiKey: WFYSUQMCIPGKKK-RNCOHGIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents
  申请人：Shinitzky Meir

  公开号：US20060173053A1

  公开（公告）日：2006-08-03

  Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C 12 -C 24 alkyl or C 10 -C 24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.

  一般式为R1-O-CO-A的脂肪醇基本酯或其药学上可接受的盐，其中R1为C12-C24烷基或C10-C24烯基，A为含有至少一个无环或环状氨基团和/或至少一个含有三级或四级氮原子的杂环芳香环的残基，具有抗炎和免疫调节作用，可用于治疗免疫介导的炎症，并作为细胞和体液反应中涉及的抗原的佐剂。
• Anti-inflamatory fatty alcohols and fatty acid esters useful as antigen carriers
  申请人：——

  公开号：US20040247604A1

  公开（公告）日：2004-12-09

  Therapeutic preparations are provided for treatment of a T-cell mediated disease or condition comprising an antigen and a carrier, wherein said antigen is an antigen recognized by inflammatory T cells associated with the pathogenesis of said T-cell mediated disease or condition, and wherein said carrier is an anti-inflammatory immunomodulator selected from: (a) a saturated or cis-unsaturated C10-C20 fatty alcohol or an ester thereof with a C1-C6 alkanoic acid; and (b) a saturated or cis-unsaturated C10-C20 fatty acid ester selected from a C1-C6 alkyl ester, a monoester with a C2-C6 polyol having a least two hydroxy groups, and a diester with glycerol.

  本发明提供了用于治疗T细胞介导的疾病或病症的治疗制剂，该制剂包含抗原和载体，其中所述抗原是与所述T细胞介导的疾病或病症的发病机制相关的炎性T细胞识别的抗原，所述载体是选自以下物质的抗炎免疫调节剂：(a) 饱和或顺式不饱和 C10-C20 脂肪醇或其与 C1-C6 烷酸的酯；和 (b) 饱和或顺式不饱和 C10-C20 脂肪酸酯，选自 C1-C6 烷基酯、与具有至少两个羟基的 C2-C6 多元醇的单酯和与甘油的二酯。
• Fatty alcohols and fatty acid esters useful for treatment of inflammation
  申请人：Cohen R Irun

  公开号：US20060183797A1

  公开（公告）日：2006-08-17

  Immunomodulators selected from: (a) a saturated or cis-unsaturated C 10 -C 20 fatty alcohol or an ester thereof with a C 1 -C 6 alkanoic acid; (b) a monoester of a C 2 -C 8 alkanediol or of Glycerol with a saturated or cis-unsaturated C 10 -C 20 fatty acid; and (c) a diester of glycerol with a saturated or cis-unsaturated C 10 -C 20 fatty acid, are useful for treatment of inflammation, particularly immunologically-mediated inflammation such as it occurs in autoimmune diseases.

  免疫调节剂选自： (a) 饱和或顺式不饱和 C 10 -C 20 饱和或顺式不饱和的 C 10 -C 20 脂肪醇或其酯与 C 1 -C 6 20 脂肪醇或其与一种 C 1 -C 6 烷酸的酯 2 -C 8 烷二醇或甘油与饱和或顺式不饱和 C 10 -C 20 脂肪酸的二酯；以及 (c) 甘油与饱和或顺式不饱和 C 10 -C 20 脂肪酸的二酯，可用于治疗炎症，特别是免疫介导的炎症，如自身免疫性疾病中出现的炎症。
• EP1385500A1
  申请人：——

  公开号：EP1385500A1

  公开（公告）日：2004-02-04
• EP1385500A4
  申请人：——

  公开号：EP1385500A4

  公开（公告）日：2004-12-29