μ-imido-dicarbonic acid dipentyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: μ-imido-dicarbonic acid dipentyl ester
• 英文别名: μ-Imido-dikohlensaeure-dipentylester；Azamalonsaeure-dipentylester；Iminodicarbonsaeure-dipentylester；pentyl N-pentoxycarbonylcarbamate
• 化学式: C₁₂H₂₃NO₄
• 分子量: 245.319
• InChiKey: DUSPEKMXCQUXKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PIPERIDINE DERIVATIVE
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20190040039A1

  公开（公告）日：2019-02-07

  The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis , multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

  本发明的目的是提供一种对结核分枝杆菌、多药耐药结核菌和/或非结核性抗酸杆菌具有优异抗菌活性的化合物。可以利用由化学式[I]表示的化合物（在该化学式中，每个符号如所附规范所述），或其盐来诊断、预防和/或治疗结核病。
• Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain
  申请人：Cid-Nunez Jose Maria

  公开号：US20080262076A1

  公开（公告）日：2008-10-23

  This invention concerns novel substituted tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards dopamine receptors, in particular dopamine D 2 receptors, towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein all substituents are defined as in Claim 1.

  本发明涉及一种新型取代四环四氢呋喃衍生物，其含有一个环状胺侧链，具有结合多巴胺受体的亲和力，特别是多巴胺D2受体，对5-HT2A和5-HT2C受体的亲和力，以及包含根据本发明的化合物的制药组合物，其用作药物，特别是用于预防和/或治疗一系列精神和神经疾病，特别是某些精神病、心血管和胃动力紊乱，并提供其生产过程。根据本发明的化合物可以用一般式（I）表示，并包括其药学上可接受的酸或碱盐、N-氧化物形式或季铵盐，其中所有取代基在权利要求书1中定义。
• Crystalline polyester-imides, process for production thereof, and use thereof
  申请人：TEIJIN LIMITED

  公开号：EP0213362A1

  公开（公告）日：1987-03-11

  Melt-moldable crystalline polyester-imides comprising units of the following formula (IA) wherein R represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 5 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, an alkoxy group having 1 to 10 carbon atoms, or a halogen atom, and n is an integer of 2 to 12, as main recurring units. The polyester-imides are prepared by (1) condensing a starting mixture containing 1 mole of an imidodicarboxylic acid and 2 to 20 moles of an aromatic monohydroxy compound under heat while distilling water out of the reaction system or (1)' condensing a starting mixture comprising 1 mole of trimellitic anhydride, 0.5 to 0.8 mole of an aliphatic diamine and 2 to 20 moles of an aromatic monohydroxy compound under heat, and thereafter (2) polycondensing the resulting reaction mixture under heat with an amount, sufficient to distill substantially all of the aromatic monohydroxy compound from the reaction system, of a diol compound or a mixture of the diol compound and an aliphatic diamine until substantially all of the aromatic monohydroxy compound is distilled out of the reaction system.

  由下式(IA)单元组成的可熔融模塑结晶聚酯-酰亚胺化合物 其中 R 代表氢原子、1 至 10 个碳原子的烷基、5 至 10 个碳原子的环烷基、6 至 10 个碳原子的芳基、7 至 12 个碳原子的芳烷基、1 至 10 个碳原子的烷氧基或卤素原子，n 是 2 至 12 的整数、 作为主要循环单元。聚酯酰亚胺是通过以下方法制备的：(1) 在加热条件下冷凝含有 1 摩尔亚胺二羧酸和 2 至 20 摩尔芳香族单羟基化合物的起始混合物，同时将水从反应体系中蒸馏出来 或 (1)'冷凝包含 1 摩尔偏苯三酸酐、0.5 至 0.8摩尔脂肪族二胺和2至20摩尔芳香族单羟基化合物的起始混合物进行加热冷凝，然后(2)在所得反应混合物中加入一定量的二元醇化合物或二元醇化合物与脂肪族二胺的混合物进行加热缩聚，直至从反应体系中蒸馏出基本上所有的芳香族单羟基化合物。
• Piperidine derivative
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US10851079B2

  公开（公告）日：2020-12-01

  The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

  本发明的目的是提供一种对结核分枝杆菌、耐多药结核菌和/或非结核酸性无菌细菌具有优异抗菌活性的化合物。由式[I]代表的化合物： (式中，各符号如所附说明书所述）的化合物或其盐类可用于诊断、预防和/或治疗结核病。
• NOVEL TETRACYCLIC TETRAHYDROFURAN DERIVATIVES CONTAINING A CYCLIC AMINE SIDE CHAIN
  申请人：Janssen Pharmaceutica NV

  公开号：EP1896456A2

  公开（公告）日：2008-03-12