5,6-dichloro-1-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5,6-dichloro-1-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole
• 英文别名: 5,6-dichloro-1-pyridin-2-ylmethyl-2-(2,2,2-trifluoroethyl)-1H-benzoimidazole；5,6-Dichloro-1-(pyridin-2-ylmethyl)-2-(2,2,2-trifluoroethyl)benzimidazole
• 化学式: C₁₅H₁₀Cl₂F₃N₃
• 分子量: 360.166
• InChiKey: KCKKYHUDHISWTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(溴甲基)吡啶氢溴酸盐 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.5h， 生成 5,6-dichloro-1-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole
  参考文献：
  名称：

  [EN] NOVEL BENZIMIDAZOLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
  [FR] MODULATEURS SELECTIFS DU RECEPTEUR D'ANDROGENE A BASE DE DERIVES BENZIMIDAZOLIQUES

  摘要：

  本发明涉及新型苯并咪唑衍生物，含有它们的药物组合物以及它们在治疗由雄激素受体调节的疾病和症状中的应用。

  公开号：

  WO2006039243A1

文献信息

• Novel benzimidazole derivatives useful as selective androgen receptor modulators (SARMS)
  申请人：Ng Raymond

  公开号：US20060111402A1

  公开（公告）日：2006-05-25

  The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

  本发明涉及新型苯并咪唑衍生物、包含它们的药物组合物及其在调节雄激素受体所致的疾病和症状中的应用。
• Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
  申请人：Ng Raymond

  公开号：US20060116412A1

  公开（公告）日：2006-06-01

  The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

  本发明涉及新的苯并咪唑衍生物、包含它们的药物组合物及其在治疗由雄激素受体调节的疾病和症状中的应用。
• Novel Benzimidazole Derivatives Useful as Selective Androgen Receptor Modulators (SARMS)
  申请人：Ng Raymond

  公开号：US20090258909A1

  公开（公告）日：2009-10-15

  The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

  本发明涉及新型苯并咪唑衍生物，包含它们的制药组合物以及它们在治疗由雄激素受体调节的疾病和症状中的应用。
• NOVEL BENZIMIDAZOLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
  申请人：Ng Raymond

  公开号：US20080119522A1

  公开（公告）日：2008-05-22

  The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

  本发明涉及新型苯并咪唑衍生物、包含它们的药物组合物以及它们在治疗通过雄激素受体调节的疾病和症状中的应用。
• MEDICINAL COMPOSITION FOR INHIBITING AMYLOID- PROTEIN DEPOSITION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2246334A1

  公开（公告）日：2010-11-03

  The present invention provides: a pharmaceutical composition for inhibiting amyloid-β protein accumulation comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient; a method for inhibiting amyloid-β protein accumulation, comprising a step of administering an effective amount of the compound of the formula (I) or a pharmaceutically acceptable salt thereof to a mammal which may be diagnosed with an amyloid-β protein-related disease; and so on.

  本发明提供了：一种用于抑制淀粉样蛋白-β蛋白积累的药物组合物，该组合物包含作为活性成分的式(I)化合物或其药学上可接受的盐；一种抑制淀粉样蛋白-β蛋白积累的方法，该方法包括向可能被诊断患有淀粉样蛋白-β蛋白相关疾病的哺乳动物施用有效量的式(I)化合物或其药学上可接受的盐的步骤；等等。