β-Methyl-glutarsaeure-bis-N-methylamid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: β-Methyl-glutarsaeure-bis-N-methylamid
• 英文别名: N,N',3-trimethylpentanediamide
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.227
• InChiKey: GUZBASSCVSKFHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲基戊二酸 、 甲胺 以 水 为溶剂， 生成 β-Methyl-glutarsaeure-bis-N-methylamid
  参考文献：
  名称：

  Lukes,R.; Pliml,J., Collection of Czechoslovak Chemical Communications, 1961, vol. 26, p. 471 - 477

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING N-METHYL-N-VINYLACETAMIDE HAVING IMPROVED STABILITY AND POLYMERIZABILITY
  申请人：Showa Denko K.K.

  公开号：EP2239250A1

  公开（公告）日：2010-10-13

  The present invention relates to a method for producing N-methyl-N-vinylacetamide, which comprises a step for controlling the N-1,3-butadienyl-N-methylacetamide content in N-methyl-N-vinylacetamide to 0.01-150 ppm. This method enables production of N-methyl-N-vinylacetamide having a stable quality, which can be controlled in stability and polymerizability as a monomer. N-methyl-N-vinylacetamide produced by the method enables production of an N-methyl-N-vinylacetamide polymer having stable physical properties such as a molecular weight.

  本发明涉及一种生产N-甲基-N-乙烯基乙酰胺的方法，其中包括控制N-1,3-丁二烯基-N-甲基乙酰胺在N-甲基-N-乙烯基乙酰胺中的含量为0.01-150 ppm的步骤。该方法使得能够生产具有稳定质量的N-甲基-N-乙烯基乙酰胺，可以在稳定性和聚合性作为单体中进行控制。通过该方法生产的N-甲基-N-乙烯基乙酰胺能够生产具有稳定物理性质，如分子量的N-甲基-N-乙烯基乙酰胺聚合物。
• HETEROCYCLIC COMPOUND
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20160229814A1

  公开（公告）日：2016-08-11

  The present invention provides a heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.

  本发明提供了一种具有RORγt抑制作用的杂环化合物。本发明涉及一种由式(I)表示的化合物：其中Ar是部分结构(1)到部分结构(5)，Q是从(Ia)-(If)组成的双价基团，B是一个环，可以具有取代基，或其盐。
• COMPOUND WITH ANTICANCER ACTIVITY
  申请人：Kyowa Kirin Co., Ltd.

  公开号：EP3778573A1

  公开（公告）日：2021-02-17

  A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).

  提供了一种具有抗癌活性的化合物或其药学上可接受的盐。所使用的是由下式（I）代表的化合物或其药学上可接受的盐： (其中，L1 和 L2 相同或不同，且各自代表由式(A)至(F)组成的组中的一个式所代表的基团，S 代表由式(S1)至(S18)组成的组中的一个式所代表的基团)。
• POLYMER CONJUGATES OF C-PEPTIDES
  申请人：Bossard Mary J.

  公开号：US20110165112A1

  公开（公告）日：2011-07-07

  The invention provides pro insulin c-peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
• US8383745B2
  申请人：——

  公开号：US8383745B2

  公开（公告）日：2013-02-26