6-(4-propyl-biphenyl-4'-ylamino)-7-bromo-2-methylquinoline-5,8-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(4-propyl-biphenyl-4'-ylamino)-7-bromo-2-methylquinoline-5,8-dione
• 英文别名: 7-Bromo-2-methyl-6-[4-(4-propylphenyl)anilino]quinoline-5,8-dione
• 化学式: C₂₅H₂₁BrN₂O₂
• 分子量: 461.358
• InChiKey: PSRUUGVJMSGODM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  溴喹那多 在 硫酸 、 硝酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.58h， 生成 2-methyl-6-(4-propyl-biphenyl-4'-ylamino)quinoline-5,8-dione 、 6-(4-propyl-biphenyl-4'-ylamino)-7-bromo-2-methylquinoline-5,8-dione
  参考文献：
  名称：

  New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain

  摘要：

  We report on the design, synthesis, and in vitro evaluation of new quinoline-5,8-dione and hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum. Of the 15 compounds, 7a-c, 8a, 9b, 11, and 15 were effective in growth inhibition with IC50 values of below 5 mu M. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.06.046

文献信息

• New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain
  作者：Hidayat Hussain、Sabine Specht、Salem R. Sarite、Achim Hoerauf、Karsten Krohn

  DOI：10.1016/j.ejmech.2012.06.046

  日期：2012.8

  We report on the design, synthesis, and in vitro evaluation of new quinoline-5,8-dione and hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum. Of the 15 compounds, 7a-c, 8a, 9b, 11, and 15 were effective in growth inhibition with IC50 values of below 5 mu M. (C) 2012 Elsevier Masson SAS. All rights reserved.