trans-3,5-dimethyl-1-(4-methoxyphenyl)-6-(4-methylphenyl)-4-propionyloxy-5,6-dihydro-1H-pyridin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-3,5-dimethyl-1-(4-methoxyphenyl)-6-(4-methylphenyl)-4-propionyloxy-5,6-dihydro-1H-pyridin-2-one
• 英文别名: [(2S,3R)-1-(4-methoxyphenyl)-3,5-dimethyl-2-(4-methylphenyl)-6-oxo-2,3-dihydropyridin-4-yl] propanoate
• 化学式: C₂₄H₂₇NO₄
• 分子量: 393.483
• InChiKey: DAEUGRPXRDLFDR-ZHRRBRCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙酰溴 、 4-methoxy-N-[(4-methylphenyl)methylidene]aniline 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 trans-3,5-dimethyl-1-(4-methoxyphenyl)-6-(4-methylphenyl)-4-propionyloxy-5,6-dihydro-1H-pyridin-2-one 、 anti-1-(p-methoxyphenyl)-3-methyl-4-p-tolylazetidin-2-one
  参考文献：
  名称：

  Synthesis of Densely Substituted Trans-Configured 4-Acylated Piperidine-2,4-diones as 3:1 Adducts of Imines and Ketenes

  摘要：

  An operationally simple method is described to form densely substituted diastereomerically pure trans-configured and potentially biologically interesting 5,6-dihydropyridone derivatives as 3:1 adducts of ketenes formed in situ from acyl bromides and aromatic imines.

  DOI：

  10.1021/jo100709y

文献信息

• Synthesis of Densely Substituted Trans-Configured 4-Acylated Piperidine-2,4-diones as 3:1 Adducts of Imines and Ketenes
  作者：José Cabrera、Tina Hellmuth、René Peters

  DOI：10.1021/jo100709y

  日期：2010.6.18

  An operationally simple method is described to form densely substituted diastereomerically pure trans-configured and potentially biologically interesting 5,6-dihydropyridone derivatives as 3:1 adducts of ketenes formed in situ from acyl bromides and aromatic imines.