(1R,2R)-1,2-cyclohexene bis(diphenylphosphinite)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2R)-1,2-cyclohexene bis(diphenylphosphinite)
• 英文别名: (1R,2R)-1,2-trans-bis-(diphenylphosphinooxy)cyclohexane；[(1R,2R)-2-diphenylphosphanyloxycyclohexyl]oxy-diphenylphosphane
• 化学式: C₃₀H₃₀O₂P₂
• 分子量: 484.515
• InChiKey: RBJWTUHNUVPCOR-LOYHVIPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯基氯化膦 、 trans-1,2-cyclohexandiol 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以90%的产率得到(1R,2R)-1,2-cyclohexene bis(diphenylphosphinite)
  参考文献：
  名称：

  手性二亚膦酸配体与环己烷或手性肌醇主链的钌配合物作为不对称氢化反应的催化剂

  摘要：

  [RuCl2(COD)] n 用手性二亚膦酸配体 (1S,2S)-1,2-trans-bis-(O-diphenylphosphino)cyclohex [(1S,2S)-14] 和三乙胺处理得到双（二亚膦酸） ) 络合物 RuHCl[(1S,2S)-14]2 (15) 收率良好。如果在该反应中使用 (rac)-1,2-反式-双-(O-二苯基膦基)环​​己烷 [(rac)-14] 代替 (1S,2S)-14，则 RuHCl[(1S) 的外消旋混合物,2S)-14]2 和 RuHCl[(1R,2R)-14]2 [(rac)-16] 形成。(rac)-16·(2.5CH2Cl2)的X射线晶体结构已经确定。(rac)-16 在异丙醇中用氢气处理导致形成 RuH2[(1S,2S)-14]2 和 RuH2[(1R,2R)-14]2[(rac)-的外消旋混合物] 17]。(rac)-17 的结构由外消旋晶体的

  DOI：

  10.1080/00958970903502744
• 作为试剂：
  描述：

  3,4-dihydro-1-vinylnaphthalene 、 氢氰酸 在 (1R,2R)-1,2-cyclohexene bis(diphenylphosphinite) 、 bis(1,5-cyclooctadiene)nickel (0) 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以80%的产率得到2-(3,4-Dihydro-naphthalen-1-yl)-propionitrile
  参考文献：
  名称：

  Nickel(0)-Catalyzed Asymmetric Hydrocyanation of 1,3-Dienes

  摘要：

  1,2-Bis-diarylphosphinites are excellent ligands for the Ni(0)-catalyzed hydrocyanation of certain types of 1,3-dienes. 1-Phenyl-1,3-butadiene,1-vinyl-3,4-dihydronaphthalene, and 1-vinylindene undergo highly regioselective hydrocyanation under ambient conditions to give exclusively the 1,2-adducts in good to excellent yields. Using bis-1,2-diarylphosphinites derived from D-glucose, the highest enantioselectivities to-date for asymmetric hydrocyanation of 1,3-dienes (70-83% ee's) have been obtained.

  DOI：

  10.1021/ol062002f

文献信息

• Process for preparing C7 intermediates and their use in the preparation on N-substituted pyrrole derivatives
  申请人：Ratiopharm GmbH

  公开号：EP1834944A1

  公开（公告）日：2007-09-19

  The present invention relates to a process for preparing C7 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids. The invention further relates to intermediates in this process.

  本发明涉及一种制备C7中间体并在制备对人体胆固醇生物合成具有效抑制作用的吡咯类衍生物中的应用的方法，更具体地涉及用于制备3,5-二羟基-7-吡咯-1-基庚酸的改进合成方法。该发明还涉及该过程中的中间体。
• Process for preparing C5 products and their use for Atorvastatin synthesis
  申请人：Ratiopharm GmbH

  公开号：EP1705175A1

  公开（公告）日：2006-09-27

  The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process

  本发明涉及一种制备C5中间体并将其用于制备一类对人类胆固醇生物合成具有抑制作用的吡咯衍生物的方法，更具体地涉及从1,4-二酮起始物质改进的合成方法，用于制备3,5-二羟基-7-吡咯-1-基庚酸。该发明还涉及该过程中的中间体。
• PROCESS FOR PREPARING PENTANOIC DIACID DERIVATIVES
  申请人：Boerner Armin

  公开号：US20110065920A1

  公开（公告）日：2011-03-17

  The present invention relates to a process for preparing pentanoic diacid derivatives useful for preparing pyrimidine derivatives, in particular as intermediates useful for preparing pyrimidine derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, such as HMG-CoA reductase inhibitors, e.g. rosuvastatin.

  本发明涉及一种制备戊二酸衍生物的方法，该衍生物用于制备嘧啶衍生物，特别是作为中间体有用于制备一类在人体中抑制胆固醇生物合成的嘧啶衍生物，例如HMG-CoA还原酶抑制剂，例如罗伐司汀。
• Process for preparing pentanoic diacid derivatives
  申请人：Ratiopharm GmbH

  公开号：EP2223909A1

  公开（公告）日：2010-09-01

  The present invention relates to a process for preparing pentanoic diacid derivatives useful for preparing pyrimidine derivatives, in particular as intermediates useful for preparing pyrimidine derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, such as HMG-CoA reductase inhibitors, e.g. rosuvastatin.

  本发明涉及一种制备戊二酸衍生物的工艺，该衍生物可用于制备嘧啶衍生物，特别是用作制备有效抑制人体胆固醇生物合成的一类嘧啶衍生物（如 HMG-CoA 还原酶抑制剂，如罗伐他汀等）的中间体。
• Method for the production of amines by reductive amination of carbonyl compounds under transfer-hydrogenation conditions
  申请人：——

  公开号：US20040267051A1

  公开（公告）日：2004-12-30

  The invention relates to the production of amines by the reaction of aldehydes or ketones with ammonia or primary or secondary amines in the presence of a hydrogen-donor and the presence of homogeneous metal catalysts of the eighth sub-group under mild conditions.

  本发明涉及醛或酮与氨或伯胺或仲胺在氢给体存在下，并在第八亚类均相金属催化剂存在下，在温和条件下反应生产胺的方法。