N-((1S,2S)-2-((2-chlorophenyl)thio)cyclohexyl)-4-methylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((1S,2S)-2-((2-chlorophenyl)thio)cyclohexyl)-4-methylbenzenesulfonamide
• 英文别名: N-[(1S,2S)-2-(2-chlorophenyl)sulfanylcyclohexyl]-4-methylbenzenesulfonamide
• 化学式: C₁₉H₂₂ClNO₂S₂
• 分子量: 395.974
• InChiKey: GFOKMCQBVZEHQN-HKUYNNGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻氯苯硫酚 、 cis-7-tosyl-7-azabicyclo[4.1.0]heptane 在 dipotassium hydrogenphosphate 、 (S)-benzyl(2-(3,5-bis(trifluoromethyl)benzamido)-3,3-dimethylbutyl)diphenylphosphonium bromide 作用下， 以 四氯化碳 为溶剂， 反应 24.0h， 以62% ee的产率得到
  参考文献：
  名称：

  Enantioselective desymmetrization of meso-aziridines with aromatic thiols catalyzed by chiral bifunctional quaternary phosphonium salts derived from α-amino acids

  摘要：

  Desymmetrization of meso-aziridines with aromatic thiols was realized by using alpha-amino acids-derived chiral quaternary phosphonium salts catalysts to provide chiral beta-amino sulfides with high yields (up to 99%) and in moderate enantioselectivities (up to 70%). (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.02.001

文献信息

• Enantioselective desymmetrization of meso-aziridines with aromatic thiols catalyzed by chiral bifunctional quaternary phosphonium salts derived from α-amino acids
  作者：Jiaxing Zhang、Dongdong Cao、Hongyu Wang、Gang Zhao、Yongjia Shang

  DOI：10.1016/j.tet.2015.02.001

  日期：2015.3

  Desymmetrization of meso-aziridines with aromatic thiols was realized by using alpha-amino acids-derived chiral quaternary phosphonium salts catalysts to provide chiral beta-amino sulfides with high yields (up to 99%) and in moderate enantioselectivities (up to 70%). (C) 2015 Elsevier Ltd. All rights reserved.