Boc-GUVVIU[T(Bn)]VUVIU-OMe

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Boc-GUVVIU[T(Bn)]VUVIU-OMe
• 英文别名: Boc-Gly-Aib-Val-Val-Ile-Aib-Thr(Bn)-Val-Aib-Val-Ile-Aib-OMe；methyl 2-methyl-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-methyl-2-[[2-methyl-2-[[(2S)-3-methyl-2-[[(2S,3R)-2-[[2-methyl-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-[[2-methyl-2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]propanoyl]amino]butanoyl]amino]butanoyl]amino]pentanoyl]amino]propanoyl]amino]-3-phenylmethoxybutanoyl]amino]butanoyl]amino]propanoyl]amino]butanoyl]amino]pentanoyl]amino]propanoate
• 化学式: C₆₇H₁₁₄N₁₂O₁₆
• 分子量: 1343.71
• InChiKey: OLOXFVAQGWREAZ-YXOJZYBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  95
• 可旋转键数：
  39
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  394
• 氢给体数：
  12
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  甲醇 、 BOC-甘氨酸 、 BOC-L-异亮氨酸 、 N-叔丁氧羰基-2-甲基丙氨酸 、 N-Boc-O-苄基-L-苏氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Boc-GUVVIU[T(Bn)]VUVIU-OMe
  参考文献：
  名称：

  Discovery of a Subnanomolar Helical d-Tridecapeptide Inhibitor of γ-Secretase

  摘要：

  gamma-Secretase is the second of two proteolytic enzymes responsible for the release of the amyloid beta-peptide implicated in the etiology of Alzheimer's disease. Here, we used solid-phase synthesis to generate a new series of helical peptides as gamma-secretase inhibitors, one of which, 11, showed an IC50 of 140 muM in a cell-free enzyme assay.

  DOI：

  10.1021/jm049788c

文献信息

• Discovery of a Subnanomolar Helical <scp>d</scp>-Tridecapeptide Inhibitor of γ-Secretase
  作者：Frédéric Bihel、Chittaranjan Das、Michael J. Bowman、Michael S. Wolfe

  DOI：10.1021/jm049788c

  日期：2004.7.1

  gamma-Secretase is the second of two proteolytic enzymes responsible for the release of the amyloid beta-peptide implicated in the etiology of Alzheimer's disease. Here, we used solid-phase synthesis to generate a new series of helical peptides as gamma-secretase inhibitors, one of which, 11, showed an IC50 of 140 muM in a cell-free enzyme assay.