吡嗪-2-羰酰氯盐酸盐 | 84473-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 吡嗪-2-羰酰氯盐酸盐
• 英文名称: pyrazinoyl chloride hydrochloride
• 英文别名: hydron;pyrazine-2-carbonyl chloride;chloride
• CAS: 84473-64-3
• 化学式: C₅H₃ClN₂O*ClH
• 分子量: 179.006
• InChiKey: ZOFWDSYSIJNFMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.28
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  吡嗪-2-羰酰氯盐酸盐 、 苯胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-phenylpyrazine-2-carboxamide
  参考文献：
  名称：

  铁-催化的邻苯胺的三氟甲基化经由吡啶酰胺辅助光致C-H官能†

  摘要：

  开发了一种方便，无氧化剂的方案，用于在紫外线照射下通过吡啶甲酰胺辅助的铁促进的C–H官能化作用对苯胺进行邻三氟甲基化。在该转化中，丙酮基本上既充当溶解反应物的溶剂，又充当廉价的自由基引发剂，以有效地从Langlois试剂中生成CF 3自由基。可以耐受广泛的底物范围，带有强吸电子基团的吡啶甲酰胺也可以以可接受的产率转化为相应的产物。此外，通过有效合成非甾体类抗炎药氟克他芬来突出这种方法的价值。

  DOI：

  10.1039/c8ob00511g

文献信息

• Novel compounds for treatment of cancer and disorders associated with angiogenesis function
  申请人：Neamati Nouri

  公开号：US20060142294A1

  公开（公告）日：2006-06-29

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.

  用于治疗癌症和与血管生成功能相关疾病的新化合物。还公开了一种制备这些化合物的方法，包括含有这些化合物的药物组合物和包装产品，一种使用这些分子治疗癌症（例如白血病、非小细胞肺癌、结肠癌、中枢神经系统癌症、黑色素瘤、卵巢癌、乳腺癌、肾癌和前列腺癌）和与血管生成功能相关疾病（例如年龄相关性黄斑变性、黄斑营养不良和糖尿病）的方法，一种监测治疗效果的方法，一种基因表达分析的方法，以及一种调控基因表达的方法。
• Potency and Selectivity of Trifluoroacetylimino and Pyrazinoylimino Nicotinic Insecticides and Their Fit at a Unique Binding Site Niche
  作者：Motohiro Tomizawa、Shinzo Kagabu、Ikuya Ohno、Kathleen A. Durkin、John E. Casida

  DOI：10.1021/jm800191a

  日期：2008.7.1

  classes of insecticides. Our studies on the nicotinic receptor structure in the neonicotinoid-bound state revealed a unique niche of about 6 A depth beyond the nitro oxygen or cyano nitrogen tip. The N-substituted imino pharmacophore was therefore extended to fill the gap. Excellent target site selectivity with high insecticidal activity and low toxicity to mammals were achieved rivaling those of the

  带有亚硝基亚氨基或氰胺基药效基团的新烟碱类激动剂是四种最重要的杀虫剂中最新的一种。我们对新烟碱类结合状态的烟碱样受体结构的研究表明，在硝基氧或氰基氮尖端以外，大约有6 A的深度具有独特的生态位。因此，N-取代的亚氨基亚基药效团被扩展以填补空白。通过与3-（6-氯吡啶基-3-基甲基）-2-三氟乙酰基亚氨基咪唑啉及其吡嗪并基嘧啶类似物的说明，可以达到对哺乳动物具有优异杀虫活性和低毒性的优异目标位点选择性，与目前的新烟碱类杀虫剂相媲美。
• Condensed Imidazole Compound And Use Thereof
  申请人：Uchikawa Osamu

  公开号：US20080167314A1

  公开（公告）日：2008-07-10

  The present invention relates to a compound represented by the formula [I] wherein X 1 , X 2 and X 3 are each an optionally substituted CH or a nitrogen atom, and any one of X 1 , X 2 and X 3 is a nitrogen atom, X 4 is an optionally substituted CH, R 1 is an optionally substituted phenyl group or an optionally substituted heterocyclic group, and R 2 is an optionally substituted pyridin-4-yl group, an optionally substituted pyridine-N-oxide-4-yl group or an optionally substituted pyrimidin-4-yl group, or a salt thereof. The compound has superior p38 MAP kinase inhibitory activity and MMP-13 production inhibitory activity, and is useful as an agent for the prophylaxis or treatment and the like of an inflammatory disease, an autoimmune disease, a debilitating disease, an osteoarticular degenerative disease, a neurodegenerative disease, a vascular disease, a neoplastic disease or an infectious disease.

  本发明涉及一种化合物，其表示为式[I]，其中X1、X2和X3分别是可选取代的CH或氮原子，且X1、X2和X3中的任意一个是氮原子，X4是可选取代的CH，R1是可选取代的苯基或可选取代的杂环基，R2是可选取代的吡啶-4-基、可选取代的吡啶-N-氧化物-4-基或可选取代的嘧啶-4-基，或其盐。该化合物具有优异的p38 MAP激酶抑制活性和MMP-13产生抑制活性，可用作预防或治疗炎症性疾病、自身免疫疾病、虚弱性疾病、骨关节退行性疾病、神经退行性疾病、血管疾病、肿瘤性疾病或感染性疾病的药物等。
• NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION
  申请人：Neamati Nouri

  公开号：US20090093489A1

  公开（公告）日：2009-04-09

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

  新型化合物用于治疗癌症和与血管生成功能相关的疾病。还公开了制备这些化合物的方法、含有这些化合物的药物组合物和包装产品、使用这些分子治疗癌症（例如白血病、非小细胞肺癌、结肠癌、中枢神经系统癌症、黑色素瘤、卵巢癌、乳腺癌、肾癌和前列腺癌）和与血管生成功能相关的疾病（例如年龄相关性黄斑变性、黄斑营养不良和糖尿病）的方法、监测治疗的方法、基因表达谱分析的方法以及调节细胞生长、细胞周期、细胞凋亡或基因表达的方法。
• Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function
  申请人：Neamati Nouri

  公开号：US20100120781A1

  公开（公告）日：2010-05-13

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

  该专利涉及新型化合物，用于治疗癌症和与血管生成功能相关的疾病。还公开了制备这些化合物的方法，含有这些化合物的药物组合物和包装产品，使用这些分子治疗癌症（例如白血病、非小细胞肺癌、结肠癌、中枢神经系统癌症、黑色素瘤、卵巢癌、乳腺癌、肾癌和前列腺癌）和与血管生成功能相关的疾病（例如年龄相关性黄斑变性、黄斑营养不良和糖尿病）的方法，监测治疗的方法，基因表达谱分析的方法，以及细胞生长、细胞周期、凋亡或基因表达的调节方法。