N-(tert-butyl)-2-(thiophen-2-yl)acetamide | 349415-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: N-(tert-butyl)-2-(thiophen-2-yl)acetamide
• 英文别名: N-(tert-butyl)-2-(2-thienyl)acetamide；N-tert-butyl-2-thiophen-2-ylacetamide
• CAS: 349415-68-5
• 化学式: C₁₀H₁₅NOS
• mdl: MFCD02860243
• 分子量: 197.301
• InChiKey: RDPDSXYHTFGMDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(tert-butyl)-2-(thiophen-2-yl)acetamide 、 ((1-(bromoethynyl)cycloheptyl)oxy)(tert-butyl)dimethylsilane 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 lithium carbonate 、 silver(l) oxide 、 双三氟甲烷磺酰亚胺银盐 作用下， 以 1,2-二氯乙烷 为溶剂， 以56 %的产率得到N-tert-butyl-2-(3-(cycloheptamethylene)thiophen-2-yl)acetamide
  参考文献：
  名称：

  一种多取代烯烃的制备方法

  摘要：

  本专利申请提供了一种多取代烯烃的制备方法。该制备方法首次开发了一种炔卤先形成烯基金属物种，最后在酰胺的促进之下进行碳氢键活化的策略形成多取代烯烃，从而实现位点选择性、立体选择性的向酰胺分子中引入烯基片段形成多取代烯烃。在惰性溶剂条件下，在过渡金属催化剂与氧化剂的共同作用下，炔卤先形成联烯酮，后在金属的作用下生成烯基金属物种，然后进行碳氢键活化的策略形成多取代烯烃。考虑到酰胺和烯烃作为天然产物、药物、材料中无处不在的官能团，该反应将有望为相关新药、新型功能材料的开发与应用提供新思路。

  公开号：

  CN117362190A
• 作为产物：
  描述：

  2-噻吩乙腈 、 醋酸叔丁酯 在 BF₃ immobilized on β-cyclodextrine functionalized silica coated CoFe₂O₄ magnetic nanoparticles 作用下， 以 neat (no solvent) 为溶剂， 反应 1.0h， 以80%的产率得到N-(tert-butyl)-2-(thiophen-2-yl)acetamide
  参考文献：
  名称：

  CoFe2O4@SiO2-NH-βCD-BF3 as a supramolecular nanocomposite: Synthesis, characterization and catalytic activity

  摘要：

  This manuscript describes synthesis of BF3-functionlized beta-cylcodextrine grafted magnetic CoFe2O4 nanaoparticles as a hybrid magnetic nano-composite (CoFe2O4@SiO2-NH-OCD-BF3). The CoFe2O4@SiO2NH-beta CD-BF3 was fabricated by grafting of 6-O-toluenesulfonyl cyclodextrin (6-Ts-beta CD) to 3-aminopropyl triethoxysilane coated magnetic CoFe2O4@SiO2 nanoparticles followed by combination with BF3. The CoFe2O4@SiO2-NH-beta CD-BF(3)was characterized by FT-IR, TGA, VSM and SEM techniques. The feasibility of using CoFe2O4@SiO2-NH-beta CD-BF3 as a magnetically recoverable catalyst was confirmed in the modified-Ritter reaction. The result showed that this novel nano-composite could serve as an efficient nanoreactor bearing super-acidic sites formed by immobilized BF3 and reuse at least for 6 times without loss in activity. (C) 2019 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2019.114219

文献信息

• Synthesis of amides using the Ritter reaction with bismuth triflate catalysis
  作者：Emmanuel Callens、Andrew J. Burton、Anthony G.M. Barrett

  DOI：10.1016/j.tetlet.2006.10.023

  日期：2006.12

  N-tert-Alkyl and aryl amides were obtained by a Ritter reaction of various nitriles with tertiary alcohols in the presence of a catalytic amount of bismuth triflate.

  ñ -叔-烷基和芳基酰胺通过与各种腈的Ritter反应，得到叔在三氟甲磺酸铋催化量的存在下的醇。
• 4-AZA INDOLE DERIVATIVES AND THEIR USE AS FUNGICIDES
  申请人：Selles Patrice

  公开号：US20100184598A1

  公开（公告）日：2010-07-22

  The present invention relates to a method of preventing and/or controlling fungal infection in plants and/or plant propagation material comprising applying to the plant or plant propagation material a fungicidally effective amount of a compound of formula (I) or a salt of N-oxide thereof. In addition, the present invention also relates to a compound of formula (I).

  本发明涉及一种防止和/或控制植物和/或植物繁殖材料真菌感染的方法，包括向植物或植物繁殖材料施加化合物(I)或其N-氧化物盐的杀菌有效量。此外，本发明还涉及化合物(I)的一种。
• US7557110B2
  申请人：——

  公开号：US7557110B2

  公开（公告）日：2009-07-07
• US8084395B2
  申请人：——

  公开号：US8084395B2

  公开（公告）日：2011-12-27
• CoFe2O4@SiO2-NH-βCD-BF3 as a supramolecular nanocomposite: Synthesis, characterization and catalytic activity
  作者：Hosein Hamadi、Zohreh Zanjani、Mahtab Yadollahi

  DOI：10.1016/j.poly.2019.114219

  日期：2020.1

  This manuscript describes synthesis of BF3-functionlized beta-cylcodextrine grafted magnetic CoFe2O4 nanaoparticles as a hybrid magnetic nano-composite (CoFe2O4@SiO2-NH-OCD-BF3). The CoFe2O4@SiO2NH-beta CD-BF3 was fabricated by grafting of 6-O-toluenesulfonyl cyclodextrin (6-Ts-beta CD) to 3-aminopropyl triethoxysilane coated magnetic CoFe2O4@SiO2 nanoparticles followed by combination with BF3. The CoFe2O4@SiO2-NH-beta CD-BF(3)was characterized by FT-IR, TGA, VSM and SEM techniques. The feasibility of using CoFe2O4@SiO2-NH-beta CD-BF3 as a magnetically recoverable catalyst was confirmed in the modified-Ritter reaction. The result showed that this novel nano-composite could serve as an efficient nanoreactor bearing super-acidic sites formed by immobilized BF3 and reuse at least for 6 times without loss in activity. (C) 2019 Elsevier Ltd. All rights reserved.