3-Methyl-1-(2-methylphenyl)-1-phenyl-1,2-butanediol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Methyl-1-(2-methylphenyl)-1-phenyl-1,2-butanediol
• 英文别名: 3-methyl-1-(2-methylphenyl)-1-phenylbutane-1,2-diol
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: JSINZAMEPSGLEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-甲基二苯甲酮 、 异丁醛 在 萘 lithium 作用下， 生成 3-Methyl-1-(2-methylphenyl)-1-phenyl-1,2-butanediol
  参考文献：
  名称：

  C,O-Dilithiated Diarylmethanols: Easy and Improved Preparation by Naphthalene-Catalysed Lithiation of Diaryl Ketones and Reactivity Toward Electrophiles

  摘要：

  The lithiation of different diaryl ketones 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in tetrahydrofuran at -30-degrees-C leads to the formation of the corresponding dianions of the type I, with Met=Li, which react with several electrophiles (E+=MeI, EtBr, PriCHO, PhCHO, cyclohexanone, MeCN) to give, after hydrolysis, the expected substituted diarylmethanols 2.

  DOI：

  10.1016/s0040-4020(01)85822-1

文献信息

• C,O-Dilithiated Diarylmethanols: Easy and Improved Preparation by Naphthalene-Catalysed Lithiation of Diaryl Ketones and Reactivity Toward Electrophiles
  作者：David Guijarro、Balbino Mancheño、Miguel Yus

  DOI：10.1016/s0040-4020(01)85822-1

  日期：1993.2

  The lithiation of different diaryl ketones 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in tetrahydrofuran at -30-degrees-C leads to the formation of the corresponding dianions of the type I, with Met=Li, which react with several electrophiles (E+=MeI, EtBr, PriCHO, PhCHO, cyclohexanone, MeCN) to give, after hydrolysis, the expected substituted diarylmethanols 2.