钙荧光指示剂-1 | 96314-96-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 钙荧光指示剂-1
• 英文名称: 2-(4-(Bis(carboxymethyl)amino)-3-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)phenyl)-1H-indole-6-carboxylic acid
• 英文别名: 2-[4-[bis(carboxymethyl)amino]-3-[2-[2-[bis(carboxymethyl)amino]-5-methylphenoxy]ethoxy]phenyl]-1H-indole-6-carboxylic acid
• CAS: 96314-96-4
• 化学式: C₃₂H₃₁N₃O₁₂
• 分子量: 649.6
• InChiKey: AMHAQOBUZCQMHN-UHFFFAOYSA-N

物化性质

• 沸点：
  1016.3±65.0 °C(Predicted)
• 密度：
  1.527±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  47
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  227
• 氢给体数：
  6
• 氢受体数：
  14

安全信息

• 安全说明：
  S22,S24/25

反应信息

• 作为产物：
  描述：

  、 disodium;selenite 、 Penicillin G potassium 、 链霉素 、 Indo-1/AM 、 Phosphate-Buffered Saline 反应 1.12h， 以Measurements with indo-1-loaded cells were obtained at excitation wavelength of 350 nM and emission wavelength of 480 and 405 nM的产率得到钙荧光指示剂-1
  参考文献：
  名称：

  Peptide analog type-B CCK receptor ligands

  摘要：

  肽类模拟物B型CCK受体配体或其药学上可接受的盐，可用于治疗中枢神经系统疾病、物质滥用、胃肠道疾病、内分泌失调、进食相关障碍以及休克、呼吸和心血管功能不足的治疗。

  公开号：

  US05340802A1

文献信息

• Fluorescent indicator dyes for calcium ions
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0178775A2

  公开（公告）日：1986-04-23

  Fluorescent indicator dyes for calcium ions of the formulae: or wherein R' is -H, -CH3, -F, -Cl or -Br; R2 is -H, -CH3, -F, -Cl, -Br, or C1-C4 alkoxy; R3 and R3 are independently H or -CO2H, -CO2R4, -CONR5R6, -SO2H, -SO2NR5R6, -SO2CF3, -COCH3, or -CN, or R3 and R3a together are -(CO)NR6(CO)-; R4 is alpha-acyloxyalkyl or a physiologically acceptable esterifying group; R5 and R6 are independently -H, methyl, or ethyl; Z is an aromatic or heteroaromatic system coupled to the 5 position of one 2-aminophenoxy ring through a trans ethylenic linkage, wherein the ethylenic linkage may itself be part of an aromatic or heteroaromatic ring system; W ia H and X is H; or W and X together are O, or NR6; Y is H; Y' is H (unless A is NR5, 0, or S); or Y and Y' together are NR5 and A is C; A and A' are independently C, N, O, or S; D is 0, N, NH, or N alkyl; Q is a double bond when D is N and a single bond otherwise; and R' is H and R8 is H or R7 and R8, together with heteroatom D, the carbon adjacent R7, and the phenyl ring adjacent to R8, form a quinoline ring system (D=N, Q=double bond).

  式中钙离子的荧光指示染料： 或 其中 R'是-H、-CH3、-F、-Cl或-Br； R2 是-H、-CH3、-F、-Cl、-Br 或 C1-C4 烷氧基； R3 和 R3 独立地为 H 或 -CO2H、-CO2R4、-CONR5R6、-SO2H、-SO2NR5R6、-SO2CF3、-COCH3 或 -CN，或 R3 和 R3a 合在一起是-(CO)NR6(CO)-； R4 是α-乙酰氧基烷基或生理上可接受的酯化基团； R5 和 R6 独立地为-H、甲基或乙基； Z 是通过反式乙烯基连接与一个 2-氨基苯氧基环的 5 位相连的芳香族或杂芳香族系统，其中乙烯基连接本身可以是芳香族或杂芳香族环系统的一部分； W ia H，X 是 H；或 W 和 X 同为 O 或 NR6； Y 是 H；Y' 是 H（除非 A 是 NR5、0 或 S）；或 Y 和 Y'同为 NR5，A 为 C； A 和 A' 独立地为 C、N、O 或 S； D 是 0、N、NH 或 N 烷基； 当 D 为 N 时，Q 为双键，否则为单键；以及 R' 是 H，R8 是 H 或 R7 和 R8 与杂原子 D、与 R7 相邻的碳以及与 R8 相邻的苯环一起构成一个喹啉环系统（D=N，Q=双键）。
• METHOD OF MEASUREMENT OF MATERIAL AND TESTPIECE
  申请人：KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU

  公开号：EP0860695A1

  公开（公告）日：1998-08-26

  A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

  一种测量被分析物的方法，包括以下步骤：根据样品中含有的被分析物的化学反应，使用包括可检测物质的形成反应的反应系统测量可检测物质，其中在包括可检测物质的形成反应的反应系统中导致层状无机化合物的存在、从而实现高灵敏度测量，稳定可检测物质以提高测量精度，提高化学反应速率以实现快速测量，即使在形成不溶性物质的反应体系中也能实现高灵敏度测量。此外，还可以提供一种用于测量被分析物的分析检测件，通过使用反应系统测量可检测物质，该反应系统包括基于样品中所含被分析物的化学反应的可检测物质的形成反应，其中检测件包括至少一个测试部分，该测试部分具有用于检测可检测物质的检测部分，并且至少在测试部分中包含分层无机化合物，从而防止染料或类似物的扩散和洗脱，实现更灵敏、更准确的简单分析，并且易于处理。
• SPECIMEN HAVING CAPABILITY OF SEPARATING SOLID COMPONENT
  申请人：ARKRAY, Inc.

  公开号：EP1271143A1

  公开（公告）日：2003-01-02

  A test strip having the capability of separating blood cells from whole blood, wherein it has a porous reagent layer comprising beads, an inorganic gel and a reagent that causes a detectable reaction with a substance to be detected, and a substrate that supports the reagent layer, wherein the beads are adhered to each other with the inorganic gel, and interstices are formed between the beads to trap a solid. The test strip can thus be used for separating blood cells from a whole blood including blood cells and plasma and detecting a substance to be detected, such as glucose, contained in plasma. The use of the test strip allows the measurement of a substance to be detected even by measurement of a transmitted light, the exhibition of good oxygen permeability, and thus can be used for measuring a substance to be detected with improved accuracy.

  一种能从全血中分离血细胞的试纸，它具有一个多孔试剂层，该试剂层由微珠、无机凝胶和能与待检测物质发生可检测反应的试剂组成，以及一个支撑试剂层的基板，其中微珠与无机凝胶相互粘附，微珠之间形成间隙以吸附固体。因此，该试纸可用于从包括血细胞和血浆在内的全血中分离出血细胞，并检测血浆中的待检测物质，如葡萄糖。使用该试纸甚至可以通过透射光的测量来检测某种物质，显示出良好的透氧性，从而可以更准确地测量某种待检测物质。
• Compositions and methods for prolonging survival of chilled platelets
  申请人：——

  公开号：US20020132225A1

  公开（公告）日：2002-09-19

  Compositions and methods for prolonging the survival of chilled platelets are provided. The compositions include agents which inhibit the liver macrophage binding to chilled platelets.

  本研究提供了延长冷冻血小板存活时间的组合物和方法。这些组合物包括抑制肝脏巨噬细胞与冷冻血小板结合的制剂。
• Specimen having capability of separating solid component
  申请人：——

  公开号：US20030044316A1

  公开（公告）日：2003-03-06

  A test strip having the capability of separating blood cells from whole blood, wherein it has a porous reagent layer comprising beads, an inorganic gel and a reagent that causes a detectable reaction with a substance to be detected, and a substrate that supports the reagent layer, wherein the beads are adhered to each other with the inorganic gel, and interstices are formed between the beads to trap a solid. The test strip can thus be used for separating blood cells from a whole blood including blood cells and plasma and detecting a substance to be detected, such as glucose, contained in plasma. The use of the test strip allows the measurement of a substance to be detected even by measurement of a transmitted light, the exhibition of good oxygen permeability, and thus can be used for measuring a substance to be detected with improved accuracy.

  一种能从全血中分离血细胞的试纸，它具有一个多孔试剂层，该试剂层由微珠、无机凝胶和能与待检测物质发生可检测反应的试剂组成，以及一个支撑试剂层的基板，其中微珠与无机凝胶相互粘附，微珠之间形成间隙以吸附固体。因此，该试纸可用于从包括血细胞和血浆在内的全血中分离出血细胞，并检测血浆中的待检测物质，如葡萄糖。使用该试纸甚至可以通过透射光的测量来检测某种物质，显示出良好的透氧性，从而可以更准确地测量某种待检测物质。