{4-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-phenyl-methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {4-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-phenyl-methanone
• 英文别名: [4-[4-(3,5-Dimethoxybenzoyl)phenoxy]phenyl]-phenylmethanone；[4-[4-(3,5-dimethoxybenzoyl)phenoxy]phenyl]-phenylmethanone
• 化学式: C₂₈H₂₂O₅
• 分子量: 438.48
• InChiKey: SDZKFPOGTOIUEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基苯甲酰氯 在 sodium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 生成 {4-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-phenyl-methanone
  参考文献：
  名称：

  A convergent route to poly(phenyl ketone ether) dendrons

  摘要：

  A series of poly(phenyl ketone) dendrons have been constructed using a convergent strategy. An aryl fluoro-substituent is deactivated towards nucleophilic substitution by protection of a para-ketone as an acetal. This allows coupling to an activated aryl fluoride. Subsequent deprotection of the acetyl group then activates the first fluoro-substituent and allows the next generation of the dendron to be added. The synthesis of higher generations is complicated by a scrambling reaction, which lowers the yields. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.012

文献信息

• A convergent route to poly(phenyl ketone ether) dendrons
  作者：A.R. Lister、S.C. Moratti

  DOI：10.1016/j.tet.2006.08.012

  日期：2006.10

  A series of poly(phenyl ketone) dendrons have been constructed using a convergent strategy. An aryl fluoro-substituent is deactivated towards nucleophilic substitution by protection of a para-ketone as an acetal. This allows coupling to an activated aryl fluoride. Subsequent deprotection of the acetyl group then activates the first fluoro-substituent and allows the next generation of the dendron to be added. The synthesis of higher generations is complicated by a scrambling reaction, which lowers the yields. (c) 2006 Elsevier Ltd. All rights reserved.