1-amino-2-methylheptane-2-sulfonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-amino-2-methylheptane-2-sulfonic acid
• 英文别名: 1-Amino-2-methylheptane-2-sulfonic acid
• 化学式: C₈H₁₉NO₃S
• 分子量: 209.31
• InChiKey: ZUSHTVRPWCIMMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-庚酮 在 甲酸 、 氨 、 双氧水 、 potassium thioacyanate 、 sodium hydride 、 silver nitrate 作用下， 以 甲醇 为溶剂， 反应 47.0h， 生成 1-amino-2-methylheptane-2-sulfonic acid
  参考文献：
  名称：

  Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen

  摘要：

  We have analyzed the level of gene coregulation, using gene expression patterns measured across the National Cancer Institute's 60 tumor cell panels (NCI60), in the context of predefined pathways or functional categories annotated by KEGG (Kyoto Encyclopedia of Genes and Genomes), BioCarta, and GO (Gene Ontology). Statistical methods were used to evaluate the level of gene expression coherence (coordinated expression) by comparing intra- and interpathway gene-gene correlations. Our results show that gene expression in pathways, or groups of functionally related genes, has a significantly higher level of coherence than that of a randomly selected set of genes. Transcriptional-level gene regulation appears to be on a "need to be" basis, such that pathways comprising genes encoding closely interacting proteins and pathways responsible for vital cellular processes or processes that are related to growth or proliferation, specifically in cancer cells, such as those engaged in genetic information processing, cell cycle, energy metabolism, and nucleotide metabolism, tend to be more modular (lower degree of gene sharing) and to have genes significantly more coherently expressed than most signaling and regular metabolic pathways. Hierarchical clustering of pathways based on their differential gene expression in the NCI60 further revealed interesting interpathway communications or interactions indicative of a higher level of pathway regulation. The knowledge of the nature of gene expression regulation and biological pathways can be applied to understanding the mechanism by which small drug molecules interfere with biological systems. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.ygeno.2005.11.011

文献信息

• Method of producing a metal phthalocyanine pigment
  申请人：Sato Tadahisa

  公开号：US20060116511A1

  公开（公告）日：2006-06-01

  A method of producing a metal phthalocyanine pigment, which contains the step of: allowing an alkali metal salt of phthalocyanine to react with a metal salt, in a solvent which is mainly composed of a sulfur-containing aprotic polar solvent.

  生产金属菲洛啉颜料的方法，包括以下步骤：允许菲洛啉的碱金属盐与金属盐在主要由含硫非质子极性溶剂组成的溶剂中发生反应。
• Topically applied circulation enhancing agent and skin and hair cosmetic and bath agent containing the same
  申请人：Sagawa Koichiro

  公开号：US20060287390A1

  公开（公告）日：2006-12-21

  A topically applied circulation enhancing agent suited for application over the entire body which has good transdermal absorptivity and causes little irritation is provided. A topically applied circulation enhancing agent is provided which contains a fatty acid ester denoted by general formula (1):

  提供一种适用于全身涂抹的促进循环的药剂，具有良好的经皮吸收性且引起少量刺激。提供一种含有一种由通用公式(1)表示的脂肪酸酯的促进循环的局部应用药剂。
• External Preparation For The Skin
  申请人：Tominaga Naoki

  公开号：US20120183492A1

  公开（公告）日：2012-07-19

  An external preparation for skin has a pH value of 2.0-5.0 and comprises: (a) 1.0-7.0 mass % of at least one of the members selected from hydroxy acids, (b) 0-0.1-3.0 mass % of a crosslinked type N,N-dimethylacrylamide-2-acrylamido-2-methylpropane sulfonic acid sodium salt copolymer, and (c) 0-0.1-3.0 mass % of an associating thickener constituted of a compound of the formula (1): R 1 —(O—R 2 ) k —OCONH—R 3 [—NHCOO—(R 4 —O) n —R 5 ] h } m (1) wherein R 1 represents a hydrocarbon group, R 2 and R 4 represent alkylene groups having 2-4 carbon atoms, which may be identical or different, or a phenylethylene group, R 3 represents a hydrocarbon group, which may have a urethane bond, R 5 represents a branched chain or secondary hydrocarbon group, m is a number of at least 2, h is a number of at least 1, k is a number within the range of 1-500, and n is a number within the range of 1-200.

  一种外用皮肤制剂的pH值为2.0-5.0，包括：(a) 1.0-7.0质量％的至少一种羟基酸成员，(b) 0-0.1-3.0质量％的交联型N，N-二甲基丙烯酰胺-2-丙烯酰胺基-2-甲基丙烷磺酸钠共聚物，以及(c) 由式(1)的化合物构成的关联增稠剂，其质量％为0-0.1-3.0： R1—(O—R2)k—OCONH—R3[—NHCOO—(R4—O)n—R5]h}m(1) 其中，R1代表烃基，R2和R4代表具有2-4个碳原子的亚烷基基团，可以相同也可以不同，或苯乙烯基团，R3代表烃基，可以具有脲键，R5代表支链或次级烃基，m至少为2，h至少为1，k在1-500范围内，n在1-200范围内。
• TOPICAL AGENT FOR DERMATOLOGICAL USE
  申请人：Nakayama Hiroki

  公开号：US20110014141A1

  公开（公告）日：2011-01-20

  The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-α-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

  本发明的目的是增强皮肤美白效果和黑色素生成的预防效果，并提供安全稳定的用于皮肤科的局部制剂。为此，4-羟基苯基-α-D-葡萄糖苷与辅助剂如抗坏血酸及其衍生物、天然药物及其提取物、羟基羧酸及其盐、油溶性甘草提取物、龙胆提取物、酚类衍生物及其盐、胎盘提取物、曲酸及其衍生物、葡萄糖胺及其衍生物、癸二酸及其衍生物、视黄醇及其衍生物、吡哆醇及其衍生物、生育酚及其衍生物、壳聚糖及其分解产物、咖啡酸衍生物、羟基肉桂酸及其衍生物、伞形科植物提取物、菌丝培养物及其提取物、植物叶片及其提取物相结合。
• Arginine derivatives and cosmetic compositions comprising the same
  申请人：AJINOMOTO CO., INC.

  公开号：EP0320976A1

  公开（公告）日：1989-06-21

  The arginine derivative of this invention can emulsify the oily and aqueous components uniformly to form a stable emulsion. It can form an O/W or W/O emulsion as desired, if the proportions of the oily and aqueous com­ponents are appropriately varied, or if another appropriate emulsifier is added. The emulsifier composition contain­ing the arginine derivative of this invention provides, for example, cosmetics for the skin such as a milky lotion and a cream, medicines for external use such as an ointment, cosmetics for the hair such as a shampoo, a rinse, a hair treatment solution and a hair conditioner, and softeners. It is particularly useful when employed for cosmetics for the hair or softeners, since the arginine derivative is adsorbed by the hair, or fibers, such as of wool or cotton, and exhibits, among others, the following effects: (1) It removes the roughness of the hair or fibers and renders them soft to the touch; (2) It smoothens the hair or fibers and renders them easy to comb; (3) It prevents the generation of static electricity which would otherwise cause the loosening of e.g. the hair; (4) It gives a pleasant handle and an oily feel, such as a smooth or moist feel; and (5) It is hardly irritating to the skin of the head or the eyes.

  本发明的精氨酸衍生物可均匀地乳化油性和水性成分，形成稳定的乳液。如果适当改变油性成分和水性成分的比例，或添加另一种适当的乳化剂，它可以根据需要形成 O/W 或 W/O 型乳液。例如，含有本发明精氨酸衍生物的乳化剂组合物可提供乳状乳液和乳霜等皮肤用化妆品、软膏等外用药物、洗发水、洗发露、头发护理液和护发素等头发用化妆品以及软化剂。精氨酸衍生物可被头发或纤维（如羊毛或棉花）吸附，除其他外，还具有以下功效，因此特别适用于头发化妆品或柔顺剂： (1) 它能去除头发或纤维的粗糙感，使其触感柔软； (2) 抚平头发或纤维，使其易于梳理； (3) 防止产生静电，否则静电会导致头发等松散； (4) 手感舒适，有油腻感，如光滑或湿润的感觉；以及 (5) 对头部皮肤或眼睛几乎没有刺激。