2,2'-bis(2-pyridylmethoxy)-(1S)-[3,3'-dibromo-1,1'-binaphthalene]

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-bis(2-pyridylmethoxy)-(1S)-[3,3'-dibromo-1,1'-binaphthalene]
• 英文别名: 2-[[3-Bromo-1-[3-bromo-2-(pyridin-2-ylmethoxy)naphthalen-1-yl]naphthalen-2-yl]oxymethyl]pyridine；2-[[3-bromo-1-[3-bromo-2-(pyridin-2-ylmethoxy)naphthalen-1-yl]naphthalen-2-yl]oxymethyl]pyridine
• 化学式: C₃₂H₂₂Br₂N₂O₂
• 分子量: 626.347
• InChiKey: CTVZZRFCVRJTEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-吡啶甲醇 、 (S)-3,3'-二溴-1,1'-联-2-萘酚 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 2,2'-bis(2-pyridylmethoxy)-(1S)-[3,3'-dibromo-1,1'-binaphthalene]
  参考文献：
  名称：

  Catalytic enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one by chiral copper catalyst

  摘要：

  A new catalytic system for enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one with thioacetylene derivatives is described. The use of a catalytic amount (20-30 mol%) of copper(II) salt with chiral bis-pyridine ligand was found to be effective in promoting the [2 + 2]-cycloaddition reaction, furnishing the corresponding bicyclic compound in good yield and good enantioselectivity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.050

文献信息

• Catalytic enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one by chiral copper catalyst
  作者：Yosuke Takenaka、Hisanaka Ito、Mineki Hasegawa、Kazuo Iguchi

  DOI：10.1016/j.tet.2006.01.050

  日期：2006.4

  A new catalytic system for enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one with thioacetylene derivatives is described. The use of a catalytic amount (20-30 mol%) of copper(II) salt with chiral bis-pyridine ligand was found to be effective in promoting the [2 + 2]-cycloaddition reaction, furnishing the corresponding bicyclic compound in good yield and good enantioselectivity. (c) 2006 Elsevier Ltd. All rights reserved.