o-Hydroxyphenylbutylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-Hydroxyphenylbutylamine
• 英文别名: 2-(4-aminobutyl)phenol
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: RPPNPGNPPUIJJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  o-Hydroxyphenylbutylamine 在 1H-咪唑-1-磺酰叠氮盐酸盐 、 碳酸氢钠 、 copper(II) sulfate 作用下， 以 甲醇 、 水 为溶剂， 反应 20.0h， 以36%的产率得到2-(4-azidobutyl)phenol
  参考文献：
  名称：

  用同价二价双位配体探测β2-肾上腺素能受体亚稳结合位点的存在。

  摘要：

  在本文中，我们报道了针对同一受体单元内正构结合位点（OBS）和亚稳结合位点（MBS）的双配位配体的开发。先前对配体与β2-肾上腺素受体（β2AR）结合的分子动力学研究表明，配体在瞬时的，保守性较低的MBSs处暂停。我们设想，MBS可以被视为变构结合位点，并由连接两个相同药效基团的同双价双位配体靶向。基于拮抗剂（S）-普萘洛尔对接至OBS和MBS中来设计此类配体并进行合成。药理学特征显示，与（S）-阿普萘洛尔相比，配体具有相似的效价和亲和力，β2/β1AR选择性略有增加，和/或β2AR的离解速率大大降低。截短的双位配体表明亚稳态药效团的主要贡献是与β2AR的疏水相互作用，而单独的接头降低了正构片段的效力。总而言之，该研究强调了靶向MBS改善配体药理作用的潜力。

  DOI：

  10.1021/acs.jmedchem.9b00595
• 作为产物：
  描述：

  4,5-二氢苯并[B]氧杂卓-2(3H)-酮 在 magnesium nitride 、 dimethyl sulfide borane 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 40.5h， 生成 o-Hydroxyphenylbutylamine
  参考文献：
  名称：

  用同价二价双位配体探测β2-肾上腺素能受体亚稳结合位点的存在。

  摘要：

  在本文中，我们报道了针对同一受体单元内正构结合位点（OBS）和亚稳结合位点（MBS）的双配位配体的开发。先前对配体与β2-肾上腺素受体（β2AR）结合的分子动力学研究表明，配体在瞬时的，保守性较低的MBSs处暂停。我们设想，MBS可以被视为变构结合位点，并由连接两个相同药效基团的同双价双位配体靶向。基于拮抗剂（S）-普萘洛尔对接至OBS和MBS中来设计此类配体并进行合成。药理学特征显示，与（S）-阿普萘洛尔相比，配体具有相似的效价和亲和力，β2/β1AR选择性略有增加，和/或β2AR的离解速率大大降低。截短的双位配体表明亚稳态药效团的主要贡献是与β2AR的疏水相互作用，而单独的接头降低了正构片段的效力。总而言之，该研究强调了靶向MBS改善配体药理作用的潜力。

  DOI：

  10.1021/acs.jmedchem.9b00595

文献信息

• Polyol and utilization thereof
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0483431A1

  公开（公告）日：1992-05-06

  The present invention relates to a polyol, polyurethane resin, rigid polyurethane foam, preparation process thereof and a preparation process of a rigid polyurethane foam composite. The polyol used in the present invention comprises a phenol resin base polyol mixed with an aminophenol base polyol or a polyphenylpolyxylylenepolyamine base polyol or a polymethylenepolyphenylpolyamine base polyol. The above polyurethane resin, foam and composite have resistance to dissolution in a hydrochlorofluorocarbons and a hydrofluorocarbons which are foaming agents having very low public hagard. The above-mentioned foams have excellent physical properties equivalent to those of conventional polyurethane foams obtained by using chlorofluorocarbons, and hence are very useful as a thermal insulation material or a thermal insulation structure for refrigerators, freezers, insulation panels, ships or vehicles.

  本发明涉及一种多元醇、聚氨酯树脂、硬质聚氨酯泡沫塑料、其制备工艺和硬质聚氨酯泡沫塑料复合材料的制备工艺。 本发明中使用的多元醇包括酚醛树脂基多元醇与氨基苯酚基多元醇或聚苯聚氧乙烯聚胺基多元醇或聚亚甲基聚苯聚胺基多元醇的混合物。 上述聚氨酯树脂、泡沫和复合材料具有抗氯氟烃和氢氟烃溶解的性能，而氯氟烃和氢氟烃是公害极低的发泡剂。 上述泡沫塑料具有与使用氯氟化碳得到的传统聚氨酯泡沫塑料同等的优异物理性能，因此非常适用于冰箱、冰柜、隔热板、船舶或车辆的隔热材料或隔热结构。
• ORGANIC PIEZOELECTRIC MATERIAL, ULTRASONIC OSCILLATOR USING THE SAME, METHOD FOR PRODUCING THE ULTRASONIC OSCILLATOR, ULTRASONIC PROBE AND ULTRASONIC MEDICAL DIAGNOSTIC IMAGING DEVICE
  申请人：Morita Kiyokazu

  公开号：US20110004102A1

  公开（公告）日：2011-01-06

  Disclosed is an organic piezoelectric material which has particularly excellent heat resistance, while exhibiting excellent transparency, surface gloss, adhesion and piezoelectric characteristics. Also disclosed are an ultrasonic oscillator used in an ultrasonic medical diagnostic imaging device, which is capable of highly sensitively receiving a high frequency wave and suitable for harmonic imaging technique, a method for producing the ultrasonic oscillator, an ultrasonic probe, and an ultrasonic medical diagnostic imaging device. The organic piezoelectric material is characterized in that the piezoelectric material is formed by laminating two or more films at the same time by a coating process.
• ORGANIC PIEZOELECTRIC MATERIAL, ULTRASONIC OSCILLATOR USING THE MATERIAL, METHOD FOR MANUFACTURING THE ULTRASONIC OSCILLATOR, ULTRASONIC PROBE, AND ULTRASONIC MEDICAL DIAGNOSTIC IMAGING DEVICE
  申请人：Morita Kiyokazu

  公开号：US20110021916A1

  公开（公告）日：2011-01-27

  Provided is an organic piezoelectric material which has excellent piezoelectric property, heat resistance property in particular. An ultrasonic oscillator, which is to be used for an ultrasonic medical diagnostic imaging device which can receive high frequencies at high sensitivity and is suitable for harmonic imaging techniques, a method for manufacturing such oscillator, and an ultrasonic probe are also provided. The ultrasonic medical diagnostic imaging device is provided by sing such oscillator, method and probe. The organic piezoelectric material is characterized by containing empty particles having an average particle diameter of 10 μm or less.
• ORGANIC PIEZOELECTRIC MATERIAL FILM, METHOD FOR PRODUCTION OF ORGANIC PIEZOELECTRIC MATERIAL FILM, METHOD FOR PRODUCTION OF ULTRASONIC OSCILLATOR, AND ULTRASONIC MEDICAL IMAGING INSTRUMENT
  申请人：Morita Kiyokazu

  公开号：US20110021918A1

  公开（公告）日：2011-01-27

  Disclosed is an organic piezoelectric material film which has little contaminants and has excellent piezoelectric properties. The organic piezoelectric material film is produced by casting a solution of an organic piezoelectric material in an organic solvent and subsequently drying the resulting product. The organic piezoelectric material film has a moisture content of 0.1 mass % or less.
• ORGANIC PIEZOELECTRIC MATERIAL FILM, METHOD FOR PRODUCTION OF THE SAME, METHOD FOR PRODUCTION OF ULTRASONIC OSCILLATOR USING THE SAME, AND ULTRASONIC MEDICAL IMAGING INSTRUMENT
  申请人：Morita Kiyokazu

  公开号：US20110021917A1

  公开（公告）日：2011-01-27

  Disclosed is an organic piezoelectric material film which has little contaminants and has excellent piezoelectric properties. The organic piezoelectric material film is produced by a solution casting process using, as raw materials, a raw material for an organic piezoelectric material and a crushed product which is produced by crushing a material produced by a solution casting process and is mainly composed of an organic piezoelectric material.