DL-N-benzyloxycarbonyl-p-hydroxyphenylglycine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DL-N-benzyloxycarbonyl-p-hydroxyphenylglycine
• 英文别名: N-carbobenzyloxy-p-hydroxyphenylglycine；2-((benzyloxycarbonyl)(4-hydroxyphenyl)amino)acetic acid；2-(4-hydroxy-N-phenylmethoxycarbonylanilino)acetic acid
• 化学式: C₁₆H₁₅NO₅
• 分子量: 301.299
• InChiKey: SKNFUEVYVFXWTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(4-羟苯基)甘氨酸 、 氯甲酸苄酯 以 N-甲基吡咯烷酮 、 水 为溶剂， 以75%的产率得到DL-N-benzyloxycarbonyl-p-hydroxyphenylglycine
  参考文献：
  名称：

  MONOMERS AND PHASE-SEPARATED BIOCOMPATIBLE POLYMER COMPOSITIONS PREPARED THEREFROM FOR MEDICAL USES

  摘要：

  该发明涉及一种新型的单体，化学式为(I)，可用于制备相分离的生物相容性聚合物或聚合物组合物。这些聚合物或聚合物组合物可能是可生物吸收和/或可生物降解的，并具有理想的机械性能，如断裂和/或疲劳韧性，这些性能以前并不是这些聚合物的主要设计标准。这些聚合物或聚合物组合物在各种医疗应用中非常有用，例如在医疗器械的制造中。因此，本公开涵盖了制备这些聚合物或聚合物组合物以及医疗器械的方法。

  公开号：

  US20120189713A1

文献信息

• [EN] DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM<br/>[FR] DERIVES DE DIPHENYLAZETIDINONE POUR LE TRAITEMENT DE TROUBLES DE METABOLISME LIPIDIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2004005247A1

  公开（公告）日：2004-01-15

  Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described.

  公式（I）的化合物：（其中变量基团如定义）药用可接受的盐、溶剂化合物、该类盐的溶剂化合物及其前药，以及它们作为治疗高脂血症的胆固醇吸收抑制剂的用途已经描述。还描述了它们的制备方法和含有它们的药物组合物。
• Diphenylazetidinone derivatives for treating disorders of the lipid metabolism
  申请人：Starke Ingemar

  公开号：US20050239766A1

  公开（公告）日：2005-10-27

  Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described.

  本文描述了公式(I)的化合物：(其中变量基团的定义如下)、药学上可接受的盐、该盐的溶剂合物、该盐的溶剂合物的前药及其用作治疗高血脂症的胆固醇吸收抑制剂的用途。还描述了它们的制造过程和含有它们的制药组合物。
• Monomers and phase-separated biocompatible polymer compositions prepared therefrom for medical uses
  申请人：Kohn Joachim B.

  公开号：US08765161B2

  公开（公告）日：2014-07-01

  The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue toughness, which have not been a primary design criteria for such polymers previously. The polymers or polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices. Therefore, methods for preparing these polymers or polymer compositions and medical devices are also encompassed by this disclosure.

  本发明涉及公式（I）的新型单体，用于制备相分离的生物相容性聚合物或聚合物组合物。这些聚合物或聚合物组合物可以是可生物吸收和/或可生物降解的，并具有理想的机械性能，例如断裂和/或疲劳韧性，这些特性以前并不是这些聚合物的主要设计标准。这些聚合物或聚合物组合物在各种医疗应用中有用，例如在制造医疗器械方面。因此，本公开还涵盖了制备这些聚合物或聚合物组合物和医疗器械的方法。
• Process for the preparation of cephalosporin derivatives using novel thioesters
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0137227A1

  公开（公告）日：1985-04-17

  By reacting a novel thioester effective as acylating agents for amines or hydrazines with a 7-aminocephalosporin derivative or a salt thereof, cephalosporin derivatives or pharmacologically acceptable salts thereof which are excellent antibiotic substances having a high antimicrobial activity can be obtained in high yield very safely.

  通过将可作为胺或肼的酰化剂的新型硫酯与 7-氨基头孢菌素衍生物或其盐反应，可以非常安全地获得高产率的头孢菌素衍生物或其药理上可接受的盐，这些衍生物是具有高抗菌活性的优良抗生素物质。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。