哌苯乙醇盐酸盐 | 4544-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 哌苯乙醇盐酸盐
• 中文别名: 盐酸哌沙酯
• 英文名称: benzilic acid-(2-piperidino-ethyl ester); hydrochloride
• 英文别名: Benzilsaeure-(2-piperidino-aethylester); Hydrochlorid；Pipethanate hydrochloride；2-piperidin-1-ylethyl 2-hydroxy-2,2-diphenylacetate;hydrochloride
• CAS: 4544-15-4
• 化学式: C₂₁H₂₅NO₃*ClH
• 分子量: 375.895
• InChiKey: ZJVKLBBPLUXEAC-UHFFFAOYSA-N

物化性质

• 熔点：
  170-171°

计算性质

• 辛醇/水分配系数(LogP)：
  -1.46
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  51
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090

文献信息

• Medicated plasters
  申请人：NITTO DENKO CORPORATION

  公开号：EP0387751A2

  公开（公告）日：1990-09-19

  Medicated plasters composed of a flexible support and a pressure-sensitive adhesive layer laminated thereon, in which said pressure-sensitive adhesive layer has an exposed surface with pH of 7 or higher and contains one of the following three components: (i) a basic physiologically active agent and an acidic substance, (ii) a salt of a basic physiologically active agent and a basic substance, and (iii) a basic physiolosically active agent and a salt of a basic physiolosically active agent.

  药用膏药，由柔性支架和层压在其上的压敏胶层组成，其中所述压敏胶层的外露表面 pH 值为 7 或更高，并含有以下三种成分之一： (i) 碱性生理活性剂和酸性物质、 (ii) 碱性生理活性剂和碱性物质的盐，以及 (iii) 碱性生理活性剂和碱性生理活性剂的盐。
• PERORAL PHARMACEUTICAL PREPARATION RELEASABLE IN LOWER DIGESTIVE TRACT
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0667148A1

  公开（公告）日：1995-08-16

  A peroral pharmaceutical preparation releasable in the lower digestive tract, having a double-layer coating structure wherein a solid drug comprising a core containing an active ingredient is coated with an inner layer comprising a cationic polymer and an outer layer comprising an anionic polymer.

  一种可在下消化道释放的口服药物制剂，具有双层包衣结构，其中固体药物由含有活性成分的内核组成，包衣内层由阳离子聚合物组成，包衣外层由阴离子聚合物组成。
• PROCESS FOR PRODUCING STABLE MEDICINAL COMPOSITION, AND PHARMACEUTICAL PREPARATION
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0729748A1

  公开（公告）日：1996-09-04

  An object of the invention is to provide a technique whereby medicines and pharmaceutical preparations can readily be stabilized by a more practicable and economical process than before. The process comprises processing 1 part by weight of a physiologically inactive powdery additive, 0.001-1 part by weight of a high-molecular-weight additive and, for example, a sublimable medicine as the essential starting materials in one batch on a multi-screw extruder. This process enables a physicochemically stable medicinal composition to be produced readily and rapidly in a large quantity and in a fundamentally continuous manner.

  本发明的目的是提供一种技术，使药物和药物制剂可以通过一种比以前更实用、更经济的工艺来稳定。该工艺包括在多螺杆挤压机上将 1 份（重量）生理上无活性的粉状添加剂、0.001-1 份（重量）高分子量添加剂和（例如）一种可升华的药物作为基本起始材料进行一批处理。这种工艺能以基本连续的方式大量、快速地生产出理化性质稳定的药物组合物。
• NOVEL TRIGLYCERIDE AND USE THEREOF
  申请人：Nitto Pharmaceutical Industries, Ltd.

  公开号：EP3305756A1

  公开（公告）日：2018-04-11

  The present invention provides a novel HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. The present invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

  本发明提供了一种新型 HYA 衍生物，该衍生物具有 HYA 固有的优异生理功能，且易于摄取和处理，并提供了其用途。 本发明涉及一种甘油三酯，其中至少有一种与甘油羟基形成酯键的脂肪酸是 10-羟基-顺式-12-十八烯酸或其光学异构体，本发明还涉及一种含有这种甘油三酯的组合物（食用脂肪或油、食品、药品、化妆品等）。
• 10-HYDROXY-CIS-12-OCTADECENOIC ACID ALKYL ESTER AND USE THEREOF
  申请人：Nitto Pharmaceutical Industries, Ltd.

  公开号：EP3305757A1

  公开（公告）日：2018-04-11

  The present invention provides a novel HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. The present invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

  本发明提供了一种新型 HYA 衍生物，它具有 HYA 所固有的优异生理功能，并且易于摄取和处理，还提供了其用途。 本发明涉及 10-羟基-顺式-12-十八烯酸的烷基酯或其光学异构体，或 10-羟基-顺式-12-十八烯酸与二水烷醇的酯或其光学异构体，以及含有这些酯的组合物（食用脂肪或油、食品、药品、化妆品等）。

表征谱图