2,5-dibromobenzophenone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-dibromobenzophenone
• 英文别名: (2,5-dibromophenyl)(phenyl)methanone；(2,5-Dibromophenyl)-phenylmethanone
• 化学式: C₁₃H₈Br₂O
• 分子量: 340.014
• InChiKey: JQHKMPQXRCJDSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-dibromobenzophenone 在 四(三苯基膦)钯 、 四氯化钛 、 potassium carbonate 、 锌 作用下， 以 四氢呋喃 、 乙醇 、 水 、 甲苯 为溶剂， 反应 20.5h， 生成
  参考文献：
  名称：

  High Fluorescence Efficiencies and Large Stokes Shifts of Folded Fluorophores Consisting of a Pair of Alkenyl-Tethered, π-Stacked Oligo-p-phenylenes

  摘要：

  A series of pure hydrocarbon fluorophores containing a pair of p-stacked oligo-p-phenylenes have been synthesized and analyzed by NMR and X-ray crystallography. They show good fluorescence in solutions and enhanced fluorescence in the aggregated state. Large Stokes shifts (up to 214 nm) have been achieved in these folded fluorophores in virtue of intramolecular energy transfer, and balanced structural rigidity and flexibility. These folded fluorophores provide perfect models for understanding the energy and charge transfer process in p-stacked systems.

  DOI：

  10.1021/acs.orglett.5b03152
• 作为产物：
  描述：

  2,5-二溴苯甲酸 在 aluminum (III) chloride 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 生成 2,5-dibromobenzophenone
  参考文献：
  名称：

  High Fluorescence Efficiencies and Large Stokes Shifts of Folded Fluorophores Consisting of a Pair of Alkenyl-Tethered, π-Stacked Oligo-p-phenylenes

  摘要：

  A series of pure hydrocarbon fluorophores containing a pair of p-stacked oligo-p-phenylenes have been synthesized and analyzed by NMR and X-ray crystallography. They show good fluorescence in solutions and enhanced fluorescence in the aggregated state. Large Stokes shifts (up to 214 nm) have been achieved in these folded fluorophores in virtue of intramolecular energy transfer, and balanced structural rigidity and flexibility. These folded fluorophores provide perfect models for understanding the energy and charge transfer process in p-stacked systems.

  DOI：

  10.1021/acs.orglett.5b03152

文献信息

• Site-selective cross-coupling of dihalogenated acetophenones and dihalogenated benzophenones with aryl titanium reagents under catalyst control
  作者：He Zhang

  DOI：10.1007/s00706-023-03101-3

  日期：2023.8

  products via palladium-catalyzed cross-coupling of aryl titanium reagents and dihalogenated benzophenone or dihalogenated acetophenone scaffolds is described. The method uses Pd(dba)2 as catalyst and 2-diisopropylphosphino-2′-dimethylaminobiphenyl as ligand in THF/NMP (3:1) (4.0 cm3) for 10 h at 0 °C. The system can tolerate various functional groups such as aldehydes, esters, etc. In the process of optimizing

  描述了一种通过芳基钛试剂和二卤代二苯甲酮或二卤代苯乙酮支架的钯催化交叉偶联选择性形成C2偶联产物的方法。该方法使用Pd(dba) 2作为催化剂，2-二异丙基膦-2'-二甲基氨基联苯作为配体，在THF/NMP (3:1) (4.0 cm 3 )中于0℃反应10小时。该体系可以耐受醛、酯等多种官能团。在优化偶联方法的过程中，我们还合成了两种新的配体，并制备了五种新的单取代芳香酮，这在本文中为首次出现。 图形概要
• Expanding the Role of Boron in New Drug Chemotypes: Properties, Chemistry, Pharmaceutical Potential of Hemiboronic Naphthoids
  作者：M. Zain H. Kazmi、Olivia M. Schneider、Dennis G. Hall

  DOI：10.1021/acs.jmedchem.3c01194

  日期：2023.10.12

  (Candida albicans) and antibacterial activity (MRSA, Escherichia coli), unveiling promising benzoxazaborines with low micromolar minimum inhibitory concentration values. Select DMPK assays of representative compounds suggest promising drug-like behavior for all four subclasses. Moreover, several drug isosteres were evaluated for anti-inflammatory and anticancer activity as appropriate.

  新的化学型和生物等排体可以在药物发现中开辟新的化学空间，并有助于满足对抗感染和其他疾病的新型药物的迫切需求。为了确定新的含硼药物化学型，本文详细介绍了拟芳香族半硼萘类、苯并恶氮杂硼烷和苯并二氮杂硼烷的综合评价。确定了四个亚类原型成员在水介质中的相关物理性质（酸度、溶解度、log P和稳定性）。这两种支架都适合药物发现中使用的常见反应，例如化学选择性 Suzuki-Miyaura、Chan-Lam 和酰胺化反应。准备了小型模型库来评估这些转化的范围，并对整个集合进行了抗真菌（白色念珠菌）和抗菌活性（MRSA、大肠杆菌）筛选，揭示了具有低微摩尔最低抑制浓度值的有前景的苯并恶唑硼烷。选择代表性化合物的 DMPK 检测表明所有四个亚类都具有良好的药物样行为。此外，还适当评估了几种药物电子等排体的抗炎和抗癌活性。
• METHOD FOR PRODUCING POLYMER COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1721922A1

  公开（公告）日：2006-11-15

  A method for polymerizing a monomer represented by the formula (1) or copolymerizing a monomer represented by the formula (1) and a monomer represented by the formula (2) in the co-presence of a condensation agent comprising a transition metal complex, to thereby produce a polymer compound represented by the formula (3): X1-Ar1-X2(1)X3-Ar2-X4(2)-(Ar1)q-(Ar2)r-(3)[X1,X2,X3 and X4 represent groups separating in the condensation, Ar1 represents a two-valent aromatic group having at least a sulfonic acid or a sulfonic acid via a connecting group as a substitutent, q represents a positive number, r represents 0 or a positive number, and the sum of q and r is 300 or more], characterized in that the above condensation agent and the above monomer are mixed at a temperature of 45°C or higher. The above method allows the production of a polymer compound which exhibits excellent fuel cell characteristics and has a high molecular weight.

  一种使式(1)所代表的单体聚合或使式(1)所代表的单体和式(2)所代表的单体在由过渡金属配合物组成的缩合剂共同存在下共聚，从而生成式(3)所代表的聚合物化合物的方法：X1-Ar1-X2(1)X3-Ar2-X4(2)-(Ar1)q-(Ar2)r-(3)[X1、X2、X3 和 X4 代表在缩合过程中分离的基团，Ar1 代表至少具有磺酸或通过连接基团作为取代基的磺酸的二价芳香基团、q代表正数，r代表0或正数，q和r之和大于等于300]，其特征在于上述缩合剂和上述单体在45℃或更高温度下混合。通过上述方法可以生产出具有优异燃料电池特性和高分子量的聚合物化合物。
• STERNPOLYMER
  申请人：Robert Bosch GmbH

  公开号：EP2456812A1

  公开（公告）日：2012-05-30
• Method for Producing Polymer Compound
  申请人：Onodera Toru

  公开号：US20100105786A1

  公开（公告）日：2010-04-29

  A method for polymerizing a monomer represented by the formula (1) or copolymerizing a monomer represented by the formula (1) and a monomer represented by the formula (2) in the co-presence of a condensation agent comprising a transition metal complex, to thereby produce a polymer compound represented by the formula (3): X 1 —Ar 1 —X 2 (1) X 3 —Ar 2 —X 4 (2) —(Ar 1 )q-(Ar 2 )r- (3) [X 1 , X 2 , X 3 and X 4 represent groups separating in the condensation, Ar 1 represents a two-valent aromatic group having at least a sulfonic acid or a sulfonic acid via a connecting group as a substituent, q represents a positive number, r represents 0 or a positive number, and the sum of q and r is 300 or more], characterized in that the above condensation agent and the above monomer are mixed at a temperature of 45° C. or higher. The above method allows the production of a polymer compound which exhibits excellent fuel cell characteristics and has a high molecular weight.