potassium RS-2-phenylbutyrate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: potassium RS-2-phenylbutyrate
• 英文别名: potassium 2-phenylbutyrate；potassium phenylbutyrate；Potassium;2-phenylbutanoate
• 化学式: C₁₀H₁₁O₂*K
• 分子量: 202.294
• InChiKey: YKWVNGULYHDAHI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.07
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium RS-2-phenylbutyrate 在 sodium methylate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 (1-silatranylmethyl) 2-phenylbutyrate
  参考文献：
  名称：

  Voronkov, M. G.; Shirchin, B.; Golovanova, N. I., Journal of general chemistry of the USSR, 1983, vol. 53, # 3, p. 494 - 496

  摘要：

  DOI：

文献信息

• Pharmaceutical composition containing at least a polymer combined with or conjugated to at least a phenylalkylcarboxylic acid salt, conjugate polymers and uses thereof
  申请人：——

  公开号：US20030171333A1

  公开（公告）日：2003-09-11

  The invention concerns a pharmaceutical composition containing at least a polymer associated or conjugated with at least a phenylalkylcarboxylic acid derivative, novel polymers conjugated with at least a phenylalkylcarboxylic acid derivative and their uses in particular in cancer treatment.

  本发明涉及一种药物组成物，该药物组成物至少包含与至少一种苯基烷基羧酸衍生物相关联或共轭的聚合物，以及与至少一种苯基烷基羧酸衍生物共轭的新型聚合物，特别是在癌症治疗中的应用。
• Synthesis, X-ray structures and NIR chiroptical properties of a series of dinuclear lanthanide(<scp>iii</scp>) complexes [Ln₂{μ-(S- or RS-pba)}₄(HBpz₃)₂]; novel configurational chirality due to non-bonding Ln⋯O interactions
  作者：Md. Abdus Subhan、Takayoshi Suzuki、Akira Fuyuhiro、Sumio Kaizaki

  DOI：10.1039/b304928k

  日期：——

  depending on the Ln(III) ionic radii: mononuclear complexes from Yb(III) to Ho(III) and dinuclear ones from Dy(III) to Nd(III). Only the dinuclear complexes for all of the Ln(III) studied were formed with a molar ratio 1 ∶ 1 ∶ 2 of Ln ∶ KHBpz3 ∶ pba. X-Ray structural analysis confirmed dinuclear structures with CH⋯π interactions and linear B⋯Ln⋯Ln⋯B arrangements for the Ln(μ-RS-pba)4Ln(HBpz3)2 (Yb , Ho , Dy

  两个系列的单核[Ln III（S-或RS -pba）（HBpz 3）2 ]（Ln = Tm，Er，Ho）和双核[Ln 2 μ-（S-或RS -pba）} 4（HBpz 3 - ）2 ]（Ln为镱，何，钆，镝，钕）络合物（PBA = RS -和/或小号-2-苯基丁酸，HBpz 3 =氢三（吡唑-1-基）硼酸盐）中制备和研究了它们的X射线结构和近红外手性。Ln：KHBpz 3摩尔比为1：2：1的合成 ：pba导致形成单核或双核复合物，具体取决于Ln（III）离子半径：从Yb（III）到Ho（III）的单核复合物以及从Dy（III）到Nd（III）的双核复合物。仅以Ln：KHBpz 3 ：pba的摩尔比1：1：2形成所研究的所有Ln（III）的双核配合物。X射线结构分析证实了Ln（μ- RS -pba）4 Ln（HBpz 3）2具有CHπ相互作用和线性B⋯Ln⋯Ln⋯B排列的双核结构。 （Yb
• A crosslinkable polymer emulsion, a method for making a crosslinked polymer film, the film produced by the method and a crosslinking agent for carboxyl-substituted polymers
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0640675A1

  公开（公告）日：1995-03-01

  A crosslinkable polymeric emulsion has a pH from 1.5 to 8.5 and includes a carboxyl-substituted latex polymer dispersed in an aqueous medium, an Iron (III) compound and an amount of a stabilizer selected from the group consisting of nonionic surfactants and protective colloids effective to sterically stabilize the emulsion. A method for making a crosslinked polymer film includes forming a layer of the crosslinkable polymer emulsion and drying the layer to form the crosslinked polymer film, the film being ionically crosslinked between carboxyl substituent groups of the polymer by Iron (III) cations. A crosslinking agent for carboxyl-substituted polymers includes particles of a water-insoluble Iron (III) compound having an average maximum characteristic linear dimension of less than or equal to 5 microns.

  可交联聚合物乳液的 pH 值为 1.5 至 8.5，包括分散在水介质中的羧基取代的胶乳聚 合物、铁(III)化合物和一定量的稳定剂，稳定剂选自由非离子表面活性剂和保护胶体组 成的组，能有效地立体稳定乳液。一种制造交联聚合物薄膜的方法包括形成一层可交联聚合物乳液并干燥该层以形成交联聚合物薄膜，该薄膜通过铁（III）阳离子在聚合物的羧基取代基团之间离子交联。羧基取代聚合物的交联剂包括平均最大特征线性尺寸小于或等于 5 微米的不溶于水的铁（III）化合物颗粒。
• Photodecarboxylative benzylations of phthalimide in pH 7 buffer: a simple access to 3-arylmethyleneisoindolin-1-ones
  作者：Vincent Belluau、Pierre Noeureuil、Elfrun Ratzke、Aleksei Skvortsov、Sonia Gallagher、Cherri Ann Motti、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2010.07.017

  日期：2010.9

  Photoadditions of phenylacetates to phthalimide in pH 7 buffer solution give the corresponding benzylated-hydroxyphthalimidines in moderate to high yields of up to 94%. In a micro-structured reactor, higher conversions and purities are achieved. With branched phenylacetates, photoaddition affords diastereoisomeric mixtures with low to moderate de values. Subsequent acid-catalyzed dehydration furnishes the corresponding 3-arylmethyleneisoindolin-1-ones in good to excellent yields and with high E-selectivities. Irradiation of the parent 3-phenylmethyleneisoindolin-1-one under oxidative conditions only leads to cis/trans-isomerization. (C) 2010 Elsevier Ltd. All rights reserved.
• COMPOSITION PHARMACEUTIQUE CONTENANT AU MOINS UN POLYMERE ASSOCIE OU CONJUGUE A AU MOINS UN SEL D'UN ACIDE PHENYLALKYLCARBOXYLIQUE, POLYMERES CONJUGUES ET LEURS APPLICATIONS
  申请人：BIODEX

  公开号：EP1289515B1

  公开（公告）日：2004-10-13