2-methoxy-N-methyl-2-phenylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-N-methyl-2-phenylacetamide
• 英文别名: methoxy-N-methylphenylacetamide
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: NQPMXTFZVDZEMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-amino-2-methyl-4-phenylisoxazol-5(2H)-one 在 溶剂黄146 、 锌 作用下， 反应 3.0h， 生成 2-methoxy-N-methyl-2-phenylacetamide
  参考文献：
  名称：

  Khalafy, Jabbar; Prager, Rolf H.; Smith, Jason A., Journal of Chemical Research, Miniprint, 1999, # 2, p. 518 - 536

  摘要：

  DOI：

文献信息

• Facile synthesis of α-alkoxyl amides <i>via</i> scandium-catalyzed oxidative reaction between ynamides and alcohols
  作者：Zhi-Xin Zhang、Bo-Han Zhu、Pei-Xi Xie、Jia-Qi Tang、Xin-Ling Li、Chunyin Zhu、Ying-Wu Yin、Long-Wu Ye

  DOI：10.1039/c8ra03842b

  日期：——

  A novel and efficient scandium-catalyzed oxidative reaction between ynamides and alcohols for the facile synthesis of various α-alkoxyl amides is reported in this paper. The reaction avoids the need for the use of α-diazo carbonyls which are unstable and may cause some safety concerns. Instead, by using alkynes as the starting materials, this protocol features readily available substrates, compatibility

  本文报道了一种新型高效的钪催化炔酰胺和醇之间的氧化反应，用于简便地合成各种α-烷氧基酰胺。该反应避免了使用不稳定且可能引起一些安全问题的α-重氮羰基化合物的需要。相反，通过使用炔烃作为起始材料，该协议具有现成的底物、与广泛的官能团的兼容性、简单的程序、温和的反应条件和高化学选择性。
• Photolysis of phenyldisic acids: evidence for unique product formation from discrete tautomers
  作者：Rolf H. Prager、Jason A. Smith

  DOI：10.1039/c39940001805

  日期：——

  3-Hydroxy-2-methyl-4-phenylisoxazol-5(2H)-one exists as four tautomers, two of which are isolated and characterised; photolysis in methanol leads to formation of products identified as arising uniquely from three of the tautomers, and the 2-phenyl analogue and phenyldisic acid undergo similar photochemical reactions.

  3-羟基-2-甲基-4-苯基异恶唑-5（2 H）-以四个互变异构体的形式存在，其中两个是分离并表征的。在甲醇中进行光解会导致形成被鉴定为唯一由三种互变异构体产生的产物，并且2-苯基类似物和苯二甲酸会经历相似的光化学反应。
• &agr;-substituted phenylacetic acid derivative, its production and agricultural fungicide containing it
  申请人：Shionogi & Co., Ltd.

  公开号：US06313150B1

  公开（公告）日：2001-11-06

  An &agr;-substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultural fungicide containing the same as the active ingredient, wherein R1 represents halogen, alkyl, OH, alkylthio, alkylsulfinyl, alkylsulfonyl, amino or nitro; Q represents aryl, heterocycle, mono- or disubstituted methyleneamino, (substituted amino-)methyl, alkyl, alkenyl, alkynyl, substituted carbonyl or substituted sulfonyl; X represents hydrogen, halogen, alkyl or OH; Y represents OH, alkylthio or amino; Z represents oxygen or sulfur; M represents oxygen, S(O)i (i being 0, 1 or 2), NR2 (R2 being hydrogen, alkyl or acyl) or a single bond; and n represents 0, 1 or 2.

  一种 &agr;-取代苯乙酸衍生物，可用作农业杀菌剂，其通式表示为 (I)，或其盐，制备该化合物的方法，制备该化合物的中间体，以及含有其作为活性成分的农业杀菌剂，其中 R1 代表卤素、烷基、羟基、烷硫基、烷基亚砜基、烷基磺酰基、氨基或硝基；Q 代表芳基、杂环、单取代或双取代亚甲基氨基、(取代氨基-)甲基、烷基、烯基、炔基、取代羰基或取代磺酰基；X 代表氢、卤素、烷基或羟基；Y 代表羟基、烷硫基或氨基；Z 代表氧或硫；M 代表氧、S(O)i (i 为 0、1 或 2)、NR2 (R2 为氢、烷基或酰基) 或单键；n 代表 0、1 或 2。
• .alpha.-substituted phenylacetic acid derivative, its production and
  申请人：Shionogi & Co., Ltd

  公开号：US05948819A1

  公开（公告）日：1999-09-07

  An .alpha.-substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultural fungicide containing the same as the active ingredient, wherein R.sup.1 represents halogen, alkyl, OH, alkylthio, alkylsulfinyl, alkylsulfonyl, amino or nitro; Q represents aryl, heterocycle, mono- or disubstituted methyleneamino, (substituted amino-)methyl, alkyl, alkenyl, alkynyl, substituted carbonyl or substituted sulfonyl; X represents hydrogen, halogen, alkyl or OH; Y represents OH, alkylthio or amino; Z represents oxygen or sulfur; M represents oxygen, S(O)i (i being 0, 1 or 2), NR.sup.2 (R.sup.2 being hydrogen, alkyl or acyl) or a single bond; and n represents 0, 1 or 2. ##STR1##

  一种α-取代苯乙酸衍生物，可用作农业杀菌剂，由通式（I）或其盐表示，其制备方法，用于其制备的中间体以及含有其作为活性成分的农业杀菌剂，其中R.sup.1代表卤素，烷基，OH，烷硫基，烷基亚砜基，烷基磺酰基，氨基或硝基；Q代表芳基，杂环，单取代或双取代亚甲基氨基，（取代氨基）甲基，烷基，烯基，炔基，取代羰基或取代磺酰基；X代表氢，卤素，烷基或OH；Y代表OH，烷硫基或氨基；Z代表氧或硫；M代表氧，S（O）i（i为0、1或2），NR.sup.2（R.sup.2为氢，烷基或酰基）或单键；n代表0、1或2。 ## STR1 ##
• AMIDE DERIVATIVE
  申请人：Nakahira Hiroyuki

  公开号：US20100056497A1

  公开（公告）日：2010-03-04

  The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R 1a is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; R 1b is an optionally substituted C 1-6 alkoxy, etc.; R 1c is a hydrogen atom, an optionally substituted C 1-6 alkoxy, etc.; R 2 is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c and R 3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH 2 ) s O—, —(CH 2 ) s N(R 4 )CO—, etc., B is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.), etc.; R 4 is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

  本发明涉及一种具有式(I)的化合物，其可用作肾素抑制剂，或其药学上可接受的盐。其中，R1a是氢原子，可选地取代的C1-6烷基等；R1b是可选地取代的C1-6烷氧基等；R1c是氢原子，可选地取代的C1-6烷氧基等；R2是氢原子，可选地取代的C1-6烷基等；R3a，R3b，R3c和R3d独立且相同或不同，每个是式：-A-B的基团（其中A是单键，-(CH2)sO-，-(CH2)sN(R4)CO-等，B是氢原子，可选地取代的C1-6烷基等）等；R4是氢原子，可选地取代的C1-6烷基等；s为0等；n为1等。