4-methyl-N-neopentylaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-neopentylaniline
• 英文别名: N-(2,2-dimethylpropyl)-4-methylaniline
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: FRIZIHKWUPNLEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙烷,三氯氟- 、 特戊醛 在 rhodium(III) chloride hydrate 、 一氧化碳 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以99%的产率得到4-methyl-N-neopentylaniline
  参考文献：
  名称：

  无需外部氢源的钌催化还原胺化

  摘要：

  使用一氧化碳作为还原剂和氯化钌（III）（0.008–2 mol％）作为催化剂，已经开发出了无外部氢源的钌催化还原胺化反应。该方法用于抗焦虑药拉达斯汀的合成。

  DOI：

  10.1021/ol503595m

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20130261117A1

  公开（公告）日：2013-10-03

  Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  本文描述了对蛋白激酶活性产生影响的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病况的方法。
• COLORED CURABLE COMPOSITION, COLOR FILTER AND METHOD OF PRODUCING COLOR FILTER, SOLID-STATE IMAGE SENSOR AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：KANNA Shinichi

  公开号：US20110217636A1

  公开（公告）日：2011-09-08

  The present invention provides a colored curable composition including a phthalocyanine pigment, a dioxazine pigment, a dye, a polymerization initiator, a polymerizable compound and a solvent; and a colored curable composition including a phthalocyanine pigment, a dye multimer having a polymerizable group and a group derived from a dipyrromethene dye, a polymerization initiator, a polymerizable compound and a solvent.

  本发明提供了一种彩色可固化组合物，包括酞菁颜料、二氧化锰颜料、染料、聚合引发剂、可聚合化合物和溶剂；以及一种彩色可固化组合物，包括酞菁颜料、具有可聚合基团和源自二吡咯甲烷染料的染料多聚物、聚合引发剂、可聚合化合物和溶剂。
• Modulators of G Protein-Coupled Receptor 88
  申请人：Bi Yingzhi

  公开号：US20110251204A1

  公开（公告）日：2011-10-13

  The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

  本公开涉及一般性的化合物，可以调节G-蛋白偶联受体88，包括这些化合物的组合物和调节G-蛋白偶联受体88的方法。
• Merging Photoinduced Iron-Catalyzed Decarboxylation with Copper Catalysis for C–N and C–C Couplings
  作者：Ni Xiong、Yang Li、Rong Zeng

  DOI：10.1021/acscatal.2c05293

  日期：2023.2.3

  dual-catalytic strategy for the radical decarboxylation functionalization of aliphatic carboxylic acids. The photoinduced ligand-to-iron charge transfer process under light was initially occurred to generate an unstabilized alkyl radical, and the copper catalyst delivered the radical and enabled the subsequent coupling reactions to form C–N or C–C bonds. By merging iron-catalyzed decarboxylation with copper catalysis

  我们报告了一种用于脂肪族羧酸自由基脱羧功能化的光诱导铁/铜双催化策略。光诱导配体到铁的电荷转移过程最初是为了产生不稳定的烷基自由基，铜催化剂传递自由基并使随后的偶联反应形成 C-N 或 C-C 键。通过将铁催化脱羧与铜催化相结合，该系统可以顺利转化各种脂肪族羧酸，从而有效地进行胺化、脱羧脱氢和烷基化。适用于多种复杂的药物或天然分子，表明该策略将有助于快速合成化合物库并有利于药物的发现。
• Ethynyl Ketene-<i>S</i>,<i>S</i>-acetals:  The Highly Reactive Electron-Rich Dienophiles and Applications in the Synthesis of 4-Functionalized Quinolines via a One-Pot Three-Component Reaction
  作者：Yu-Long Zhao、Wei Zhang、Shuang Wang、Qun Liu

  DOI：10.1021/jo070069q

  日期：2007.6.1

  An efficient synthetic method for 4-functionalized quinoline derivatives, 4-((1,3-dithian-2-ylidene)methyl)quinolines, has been developed. Mediated by trifluoromethanesulfonic acid, ethynyl ketene-S,S-acetals can react in a one-pot procedure with various arylamines and aldehydes under mild conditions to give the corresponding quinoline derivatives in good to high yields via a consecutive arylimine formation, regiospecific aza-Diels-Alder (Povarov) reaction, and reductive amination.