N¹,N²-dimethyl-dl-isoasparagine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N¹,N²-dimethyl-dl-isoasparagine
• 英文别名: N¹,N²-Dimethyl-dl-isoasparagin；inakt.Methylamino-bernsteinsaeure-α-mono-methylamid；(N-Methyl-dl-asparaginsaeure)-α-mono-methylamid；3,4-Bis(methylamino)-4-oxobutanoic acid
• 化学式: C₆H₁₂N₂O₃
• 分子量: 160.173
• InChiKey: OTBBSCQKLLOVBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲醇 、 N¹,N²-dimethyl-dl-isoasparagine 、 碘甲烷 、 alkaline earth salt of/the/ methylsulfuric acid 生成 四甲基碘化铵 、 (E)-4-(methylamino)-4-oxobut-2-enoic acid
  参考文献：
  名称：

  Koerner; Menozzi, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1894, vol. <5>3 I, p. 158

  摘要：

  DOI：
• 作为产物：
  描述：

  N-methyl-dl-aspartic acid bis-methylamide 在 水 作用下， 生成 N¹,N²-dimethyl-dl-isoasparagine
  参考文献：
  名称：

  Koerner; Menozzi, Gazzetta Chimica Italiana, 1889, vol. 19, p. 427

  摘要：

  DOI：

文献信息

• BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF
  申请人：Keck Gary E.

  公开号：US20110269713A1

  公开（公告）日：2011-11-03

  Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

  本文描述的是三环大环内酯。这些大环内酯对蛋白激酶C（PKC）具有很高的结合亲和力。本文描述的化合物可用于多种治疗应用，包括癌症和阿尔茨海默病的预防和治疗。本文描述的化合物还可以用于治疗记忆丧失。本文还描述了生产大环内酯的方法。这些方法允许在更少的步骤中以更高的置换度和特异性高产合成大环内酯。
• CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS
  申请人：McManus Samuel P.

  公开号：US20120100096A1

  公开（公告）日：2012-04-26

  The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.

  本发明涉及小干扰核酸（siNA）的结合物。本发明描述了适用于向患者施用的siNA组成物。还描述了传递这些组成物的方法。
• POLYMER CONJUGATES OF GLP-1
  申请人：BOSSARD Mary J.

  公开号：US20130096258A1

  公开（公告）日：2013-04-18

  Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-1 moiety possesses an N-methyl substituent.

  GLP-1分子的共轭物可以共价地附着在一个或多个水溶性聚合物上。例如，GLP-1聚合物共轭物可以包括一个GLP-1分子，在其N-末端可释放地附着在水溶性聚合物上。GLP-1聚合物共轭物可以包括一个GLP-1分子共价地附着在水溶性聚合物上，其中GLP-1分子具有一个N-甲基取代基。
• POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20160022828A1

  公开（公告）日：2016-01-28

  The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

  本发明提供了通过共价结合水溶性寡聚体进行化学修饰的肽。本发明的结合物在通过任何一种给药途径进行给药时，表现出与未附着水溶性寡聚体的肽不同的特征。
• Conjugates of a G-CSF moiety and a polymer
  申请人：Bossard J. Mary

  公开号：US20070092482A1

  公开（公告）日：2007-04-26

  Conjugates of a G-CSF moiety and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.