5,8-dioxo-dodecanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 5,8-dioxo-dodecanedioic acid
• 英文别名: 5,8-Dioxo-dodecandisaeure；5,8-Dioxododecanedioic acid
• 化学式: C₁₂H₁₈O₆
• 分子量: 258.271
• InChiKey: QCVXQPRSKWPYHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  戊二酸单乙酯酰氯 在 盐酸 、 palladium on activated charcoal 、 Lindlar's catalyst 、 乙醚 作用下， 生成 5,8-dioxo-dodecanedioic acid
  参考文献：
  名称：

  Ernest, Collection of Czechoslovak Chemical Communications, 1954, vol. 19, p. 1179,1188

  摘要：

  DOI：

文献信息

• Amorphous sulfopolyesters
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0136899A2

  公开（公告）日：1985-04-10

  Amorphous sulfopolyesters which are the esterification product of glycols and dicarboxylic acids and, optionally, hydroxycarboxylic acids, of which at least about 35 mole percent are ortho-dicarboxylic acids.

  无定形硫聚酯，它是乙二醇和二羧酸以及羟基羧酸的酯化产物，其中至少约 35 摩尔%为正二羧酸。
• KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Esperion Therapeutics Inc.

  公开号：EP1326822A2

  公开（公告）日：2003-07-16
• US4480085A
  申请人：——

  公开号：US4480085A

  公开（公告）日：1984-10-30
• [EN] KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] COMPOSES DE FONCTION CETONE ET COMPOSITIONS POUR LA REGULATION DU TAUX DE CHOLESTEROL, ET UTILISATIONS ASSOCIEES
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2002030860A2

  公开（公告）日：2002-04-18

  The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
• Ernest, Collection of Czechoslovak Chemical Communications, 1954, vol. 19, p. 1179,1188
  作者：Ernest

  DOI：——

  日期：——