噻唑烷-4-甲酸乙酯 | 51977-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 噻唑烷-4-甲酸乙酯
• 中文别名: L-噻唑烷-4-甲酸乙酯；四氢噻唑-4-甲酸乙酯；L-硫代脯氨酸乙酯；乙基噻唑烷-4-羧酸
• 英文名称: ethyl L-thiazolidine-4-carboxylate
• 英文别名: Thiazolidine-4-carboxylic acid ethyl ester；ethyl 1,3-thiazolidine-4-carboxylate；4-ethoxycarbonylthiazolidine；(+/-)-(R)-thiazolidine-4-carboxylic acid ethyl ester；(+/-)-(R)-Thiazolidin-4-carbonsaeure-aethylester；Ethyl thiazolidine-4-carboxylate
• CAS: 51977-21-0
• 化学式: C₆H₁₁NO₂S
• mdl: MFCD08457699
• 分子量: 161.225
• InChiKey: ZRBNETYZYOXTLS-UHFFFAOYSA-N

物化性质

• 沸点：
  90-91 °C(Press: 3 Torr)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  噻唑烷-4-甲酸乙酯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 silver carbonate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.0h， 生成 3-acetylamino-3-ethoxycarbonyldihydrothieno[2,3-g]quinolin-4,9-dione
  参考文献：
  名称：

  Reaction between quinone and thiazolidine. A study on the formation mechanism of new antiproliferative quinolindiones

  摘要：

  Reaction between quinolinquinone and thiazolidine in basic medium was investigated. 2-Arylthiazolidine-4-carboxylic acid ethyl esters undergo two different cleavages in basic medium, yielding the 1-aryl-2-azadiene and a thiolic species. In the presence of quinolinquinone, the isomeric 1-aryl-3-ethoxycarbonyl-pyridoisoquinolin-5,10-diones and 3-amino-3-ethoxycarbonyl-dihydrothienoquinolin-4,9-diones are formed by a hetero-Diels-Alder reaction and 1,4-Michael addition reaction, respectively. A mechanism for the formation of the reaction products is presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.06.098
• 作为产物：
  描述：

  (R)-噻唑烷-4-羧酸乙酯 在 氢氧化钾 作用下， 生成 噻唑烷-4-甲酸乙酯
  参考文献：
  名称：

  The Reaction of Djenkolic Acid and Aqueous Calcium Hydroxide. The Isolation and Identification of Racemic Thiazolidine-4-carboxylic Acid

  摘要：

  DOI：

  10.1021/ja01564a033

文献信息

• Method of treating hyperlipidemia with 4-(monoalkylamino)benzoic acid
  申请人：American Cyanamid Company

  公开号：US04485105A1

  公开（公告）日：1984-11-27

  This disclosure describes a method of treating hyperlipidemia and atherosclerotic lesions with 4-(monoalkylamino)benzoic acid amides and compositions therefor.

  这份披露描述了使用4-(单烷基氨基)苯甲酸酰胺及其组合物治疗高脂血症和动脉粥样硬化病变的方法。
• 4-(Monoalkylamino)benzoic acid imidates
  申请人：American Cyanamid Company

  公开号：US04136256A1

  公开（公告）日：1979-01-23

  This disclosure describes 4-(monoalkylamino)benzoic acid amides and imidates useful as hypolipidemic and antiatherosclerotic agents.

  这份披露描述了作为降脂和抗动脉粥样硬化药物有用的4-(单烷基氨基)苯甲酸酰胺和亚胺。
• Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane,
  申请人：American Cyanamid Company

  公开号：US04348399A1

  公开（公告）日：1982-09-07

  This disclosure describes novel 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives useful as hypolipidemic and antiatherosclerotic agents.

  这份披露描述了作为降脂和抗动脉粥样硬化药物有用的新型4-(单烷基氨基)苯基烷烯、烯烃和炔烃羟基醇、醛、羧酸和衍生物。
• Anti-atherosclerotic agents
  申请人：American Cyanamid Company

  公开号：US04440940A1

  公开（公告）日：1984-04-03

  This disclosure describes 2- or 3-[(unsaturated or cyclopropylated alkyl)amino]phenyl compounds and derivatives useful as hypolipidemic and antiatherosclerotic agents.

  这份披露描述了作为降脂和抗动脉粥样硬化药物有用的2-或3-[(不饱和或环丙基化烷基)氨基]苯基化合物和衍生物。
• Heterocyclic compounds containing nitrogen and sulfur, pharmaceutical
  申请人：Richter Gedeon Vegyeszeti Gyar Rt.

  公开号：US05096902A1

  公开（公告）日：1992-03-17

  The invention relates to novel nitrogen- and sulfur-containing heterocyclic compounds of the formula (I), acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## Ar stands for an optionally mono- or polysubstituted aryl or heteroaryl group; R.sup.1 means a carbonyl or (C.sub.2-6 alkenyl)carbonyl group; R.sup.2 stands for hydrogen C.sub.1-6 alkyl, phenyl or phenyl (C.sub.1-4 alkyl) group; R.sup.3 means hydrogen or (C.sub.1-6 alkoxy)carbonyl group; R.sup.4 and R.sup.5 stand, independently from each other, for hydrogen or C.sub.1-6 alkyl group; R.sub.6 ogen, C.sub.1-6 alkyl group or halophenyl group; m is 0 or 1; and n is 1 or 2, with the proviso that R.sup.2 means hydrogen when m is 0. The compounds of formula (I) show a significant cerebral antihypoxic action and thus, they can be used for the treatment of diseases caused by hypoxic brain damages such as e.g. the senile dementia, Alzheimer's disease or disturbances of the cognitive function.

  该发明涉及一种新的含氮和硫杂环化合物，其化学式为（I），以及其酸盐、含有它们的药物组合物和制备它们的方法。在化学式（I）中，Ar代表可选择地单取代或多取代的芳基或杂芳基；R1表示羰基或（C2-6烯基）羰基基团；R2代表氢、C1-6烷基、苯基或苯基（C1-4烷基）基团；R3表示氢或（C1-6烷氧基）羰基基团；R4和R5独立地代表氢或C1-6烷基基团；R6 ogen、C1-6烷基基团或卤苯基团；m为0或1；n为1或2，但R2在m为0时表示氢。化合物（I）表现出显著的脑部抗缺氧作用，因此可以用于治疗由缺氧性脑损伤引起的疾病，如老年性痴呆、阿尔茨海默病或认知功能障碍。