2,6,10-triaza-1,11-bis-(3,5-di-t-butyl-4-hydroxyphenyl)undecane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6,10-triaza-1,11-bis-(3,5-di-t-butyl-4-hydroxyphenyl)undecane
• 英文别名: 1,9-bis[(3,5-di-t-butyl-4-hydroxyphenyl)methyl]-1,5,9-triazanonane；2,6-Ditert-butyl-4-[[3-[3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylamino]propylamino]propylamino]methyl]phenol
• 化学式: C₃₆H₆₁N₃O₂
• 分子量: 567.899
• InChiKey: QZFQVDGGPYGJIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  41
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  76.6
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 2,6,10-triaza-1,11-bis-(3,5-di-t-butyl-4-hydroxyphenyl)undecane 在 氢氧化钾 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 Bis-{3-[tert-butoxycarbonyl-(3,5-di-tert-butyl-4-hydroxy-benzyl)-amino]-propyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Dibenzyl Polyamine Analogs - A New Class of Radioprotective Agents

  摘要：

  A series of N-benzyl norspermidine analogues was prepared and evaluated as radiation protective agents. We have previously reported the results of an in vitro assay which showed this type of polyamine analogue was taken up by HeLa cells where it localized in the nucleus in high concentrations. The compounds were further modified to include radical scavenging functionality in an attempt to deliver the radical scavenging molecule to the nucleus and protect DNA from damage during irradiation. The best protective activity was observed with the parent dibenzylpolyamine analogue, suggesting that the radiation protective acitivity seen with the compound may not involve radical scavenging. (C) 1994 Academic Press, Inc.

  DOI：

  10.1006/bioo.1994.1029
• 作为产物：
  描述：

  3,3'-二氨基二丙基胺 、 3,5-二叔丁基-4-羟基苯甲醛 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成 2,6,10-triaza-1,11-bis-(3,5-di-t-butyl-4-hydroxyphenyl)undecane
  参考文献：
  名称：

  Dibenzyl Polyamine Analogs - A New Class of Radioprotective Agents

  摘要：

  A series of N-benzyl norspermidine analogues was prepared and evaluated as radiation protective agents. We have previously reported the results of an in vitro assay which showed this type of polyamine analogue was taken up by HeLa cells where it localized in the nucleus in high concentrations. The compounds were further modified to include radical scavenging functionality in an attempt to deliver the radical scavenging molecule to the nucleus and protect DNA from damage during irradiation. The best protective activity was observed with the parent dibenzylpolyamine analogue, suggesting that the radiation protective acitivity seen with the compound may not involve radical scavenging. (C) 1994 Academic Press, Inc.

  DOI：

  10.1006/bioo.1994.1029

文献信息

• Polyamine phenols as radioprotective agents
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0495450A2

  公开（公告）日：1992-07-22

  The present invention relates to certain polyamine phenols which are useful as radioprotective agents.

  本发明涉及某些可用作辐射防护剂的多胺酚。
• JPH04334354A
  申请人：——

  公开号：JPH04334354A

  公开（公告）日：1992-11-20
• US5354782A
  申请人：——

  公开号：US5354782A

  公开（公告）日：1994-10-11