N-(2-piperidon-2-yl)trifluoromethanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(2-piperidon-2-yl)trifluoromethanesulfonamide
• 英文别名: trifluoro-N-(2-piperidinylidene)methanesulfonamide；1,1,1-trifluoro-N-(2,3,4,5-tetrahydropyridin-6-yl)methanesulfonamide
• 化学式: C₆H₉F₃N₂O₂S
• 分子量: 230.211
• InChiKey: FXNDYPRGVCBXSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  哌啶酮 、 三氟甲磺酰胺 在 三乙胺 、 三氯氧磷 作用下， 以 氯苯 为溶剂， 反应 5.0h， 以35%的产率得到N-(2-piperidon-2-yl)trifluoromethanesulfonamide
  参考文献：
  名称：

  Facile One-Pot Synthesis of Cyclic N-Sulfonylamidines from Lactam and Sulfonamide

  摘要：

  A simple method has been developed for one-pot synthesis of five-, six- and seven-membered cyclic N-sulfonylamidines from lactams and sulfonamides under mild conditions. The method involves a Vilsmeier like reaction promoted by phosphoryl chloride. Detailed synthetic studies showed that the corresponding substituted N-sulfonylamidines were obtained in moderate to good yields.

  DOI：

  10.3987/com-15-13307

文献信息

• Facile One-Pot Synthesis of Cyclic N-Sulfonylamidines from Lactam and Sulfonamide
  作者：Abudureheman Wusiman、Ayinigeer Mulati

  DOI：10.3987/com-15-13307

  日期：——

  A simple method has been developed for one-pot synthesis of five-, six- and seven-membered cyclic N-sulfonylamidines from lactams and sulfonamides under mild conditions. The method involves a Vilsmeier like reaction promoted by phosphoryl chloride. Detailed synthetic studies showed that the corresponding substituted N-sulfonylamidines were obtained in moderate to good yields.