5-(4-methoxyphenyl)-perhydro-1,3,5-dithiazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-methoxyphenyl)-perhydro-1,3,5-dithiazine
• 英文别名: 5-(4-methoxyphenyl)-1,3,5-dithiazinane；5-(4-Methoxyphenyl)-1,3,5-dithiazinane
• 化学式: C₁₀H₁₃NOS₂
• 分子量: 227.351
• InChiKey: HVRPDDJEUIEXIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  63.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氢-5-甲基-4H-1,3,5-二噻嗪 、 甲氧苯胺 在 samarium(III) nitrate hexahydrate 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以70%的产率得到5-(4-methoxyphenyl)-perhydro-1,3,5-dithiazine
  参考文献：
  名称：

  通过 N-甲基-1,3,5-二噻嗪烷与芳胺和肼的氨基转移反应合成 N-取代的二噻嗪烷的有效方法

  摘要：

  已经开发了基于 N-甲基-1,3,5-二噻嗪烷与芳胺和肼在 Sm 和 Co 催化剂存在下的氨基转移反应合成 N-取代二噻嗪烷的有效方法。

  DOI：

  10.3998/ark.5550190.0012.810

文献信息

• Synthesis, crystal structure, and interconversions of new N-aryl-1,3,5-dithiazinanes, 1,3,5-thiadiazinanes, and 1,5-dithia-3,7-diazacyclooctanes
  作者：V. R. Akhmetova、Z. T. Niatshina、G. R. Khabibullina、I. S. Bushmarinov、A. O. Borisova、Z. A. Starikova、L. F. Korzhova、R. V. Kunakova

  DOI：10.1007/s11172-010-0196-y

  日期：2010.5

  mixture in the synthesis of N-aryl-substituted 1,3,5-dithiazinanes, 1,3,5-thiadiazinanes, and 1,5-dithia-3,7-diazacyclooctanes has been studied depending on the type and mutual arrangement of substituents in the starting anilines, ratio of reagents, temperature, and reaction time. Conformation of the synthesized heterocycles in crystal has been found by X-ray diffraction. Interconversion of the heterocycles

  苯胺与 CH2O-H2S 硫甲基化混合物在合成 N-芳基取代的 1,3,5-二噻嗪、1,3,5-噻二嗪和 1,5-二噻-3,7-二氮杂环辛烷中的多组分反应的化学选择性已根据起始苯胺中取代基的类型和相互排列、试剂比例、温度和反应时间进行了研究。已通过 X 射线衍射发现晶体中合成杂环的构象。杂环的相互转化显示了 N-芳基-1,3,5-二噻嗪烷的稳定性。
• ——
  作者：S. R. Khafizova、V. R. Akhmetova、R. V. Kunakova、U. M. Dzhemilev

  DOI：10.1023/a:1026021124424

  日期：——

  Primary aromatic amines were thiomethylated by formaldehyde and hydrogen sulfide. N-Substituted 1,3-thiazetidines, 4,5-dihydro-1,3,5-dithiazines, 3,4,5,6-tetrahydro-2H-1,3,5-thiadiazines, and 4,5-dihydro-1,3,5-oxathiazines were prepared for the first time starting from meta- and para-toluidines, meta-, para-, and ortho-anisidines, and para-xylidine. Amines characterized by higher mobility of hydrogen atoms produced previously unknown four-membered thiazetidines, whereas amines characterized by lower mobility of hydrogen atoms gave six-membered thiadiazines. The sorption properties with respect to silver were studied for the compounds, which were prepared from p-toluidine and p-anisidine.
• Efficient method for a synthesis of N-substituted dithiazinanes via transamination of N-methyl-1,3,5-dithiazinane with arylamines and hydrazines
  作者：Zalifa T. Niatshina、Natal’ya N. Murzakova、Inna V. Vasilieva、Elena B. Rakhimova、Vnira R. Akhmetova、Askhat G. Ibragimov

  DOI：10.3998/ark.5550190.0012.810

  日期：——

  The efficient method for a synthesis of N-substituted dithiazinanes based on the transamination reaction of N-methyl-1,3,5-dithiazinane with arylamines and hydrazines in the presence of Sm and Co catalysts has been developed.

  已经开发了基于 N-甲基-1,3,5-二噻嗪烷与芳胺和肼在 Sm 和 Co 催化剂存在下的氨基转移反应合成 N-取代二噻嗪烷的有效方法。