(E)-methyl 2-methoxy-4-(prop-1-enyl)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-methyl 2-methoxy-4-(prop-1-enyl)benzoate
• 英文别名: methyl 2-methoxy-4-[(E)-prop-1-enyl]benzoate
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: RMFLWTCRPMVYPF-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-methoxy-4-methoxycarbonylcinnamic acid 在 iron(III) chloride 、 二叔丁基过氧化物 作用下， 以 二甲基亚砜 为溶剂， 反应 12.0h， 以20%的产率得到(E)-methyl 2-methoxy-4-(prop-1-enyl)benzoate
  参考文献：
  名称：

  Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions

  摘要：

  It is the first time to find that iron-catalyzed decarboxylative methylation of alpha,beta-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-tert-butyl peroxide (DTBP) was employed not only as the oxidant, but also as the methyl source. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.06.014

文献信息

• Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions
  作者：Guangwei Rong、Defu Liu、Linhua Lu、Hong Yan、Yang Zheng、Jie Chen、Jincheng Mao

  DOI：10.1016/j.tet.2014.06.014

  日期：2014.8

  It is the first time to find that iron-catalyzed decarboxylative methylation of alpha,beta-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-tert-butyl peroxide (DTBP) was employed not only as the oxidant, but also as the methyl source. (C) 2014 Elsevier Ltd. All rights reserved.